Wikiversity

Lentinano Alerta sobre risco à saúde

Nome IUPAC	β-D-glucopyranosyl-(1→6)-[β-D-glucopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→3)β-D-glucopyranosyl-(1→3)]-β-D-glucopyranose
Outros nomes	(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6R)-2,3,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,5-dihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Identificadores
Número CAS	37339-90-5
PubChem	37723
Código ATC	L03AX01
Página de dados suplementares
Estrutura e propriedades	n, ε_r, etc.
Dados termodinâmicos	Phase behaviour Solid, liquid, gas
Dados espectrais	UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a materiais sob condições normais de temperatura e pressão Referências e avisos gerais sobre esta caixa. Alerta sobre risco à saúde.

Lentinano é um betaglucano com uma ligação glicosídica β-1,3:β-1,6.^[1] É um polissacarídeo anti-tumoral extraído do cogumelo shiitake (Lentinula edodes).^[1] Tem um peso molecular de aproximado de 500,000 Da. A investugação sobre o lentinano foi efectuada pela companhia farmacêutica japonesa Ajinomoto.^[2]

Pesquisa sobre os efeitos do lentinano

Uma experiência in vitro mostrou que o lentinano estimulava a produção de glóbulos brancos linhagem celular humana U937.^[3] Foi também demonstrado que uma mistura farmacológica (MC-S) de lentinano, PSK, Ganoderma lucidum e Astragalus propinquus estimulava a produção de glóbulos brancos in vitro.^[4]

Um experiência in vivo feita em ratos, revelou que o lentinano é activo oralmente (o uso clínico da droga é por administração intravenosa).^[5] Estudos clínicos limitados em paciente com cancro associaram o lentinano com uma maior taxa de sobrevivência, melhor qualidade de vida, e menor recorrência de cancro.^[6]^[7]^[8]^[9]^[10]^[11]^[12]^[13]

Ver também

Cogumelos medicinais
Shiitake
Smith JE, Rowan NJ, Sullivan R Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments Cancer Research UK, 2001

Este artigo foi inicialmente traduzido, total ou parcialmente, do artigo da Wikipédia em inglês cujo título é «Lentinan», especificamente desta versão.

Ligações externas

«Lentinan effects (antitumor and others)» (em inglês)

Referências

↑ ^a ^b Cancer Guide Inclui muitos abstractos
↑ http://sci.cancerresearchuk.org/labs/med_mush/final_pdfs/chapt5.pdf
↑ Sia GM, Candlish JK. (1999), «Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line.», Phytother Res., 13 (2): 133–7, PMID 10190187, doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O
↑ Clark D, Adams M. (2007), «Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support on non-stimulated human lymphocytes.», Austr. J. Med. Herbal., 19: 108-111
↑ Ng ML, Yap AT. (2002), «Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes).», National University of Singapore, J Altern Complement Med., 8 (5): 581–9, PMID 12470439, doi:10.1089/107555302320825093
↑ Yang P, Liang M, Zhang Y, Shen B. (2008), «Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.», Adv Ther., 25 (8): 787–94, PMID 18670743, doi:10.1007/s12325-008-0079-x
↑ Nimura H, Mitsumori N, Takahashi N, (2006), «[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]», Gan to Kagaku Ryoho., 33 (1): 106–9, PMID 16897983
↑ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999), «A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.», Hepatogastroenterology., 46 (28): 2662–8, PMID 10522061
↑ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (2009). «Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer». Anticancer Res. 29 (7): 2739–45. PMID 19596954
↑ Hazama S, Watanabe S, Ohashi M; et al. (2009). «Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer». Anticancer Res. 29 (7): 2611–7. PMID 19596936
↑ Kataoka H, Shimura T, Mizoshita T; et al. (2009). «Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life». Hepatogastroenterology. 56 (90): 547–50. PMID 19579640
↑ Isoda N, Eguchi Y, Nukaya H; et al. (2009). «Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma». Hepatogastroenterology. 56 (90): 437–41. PMID 19579616
↑ Shimizu K, Watanabe S, Watanabe S; et al. (2009). «Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer». Hepatogastroenterology. 56 (89): 240–4. PMID 19453066

Este artigo sobre fármacos é um esboço. Você pode ajudar a Wikipédia .

[CancerGuide-1] Cancer Guide Inclui muitos abstractos

[2] ttp://sci.cancerresearchuk.org/labs/med_mush/final_pdfs/chapt5.pdf

[pmid_=_10190187-3] Sia GM, Candlish JK. (1999), «Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line.», Phytother Res., 13 (2): 133–7, PMID 10190187, doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O

[4] Clark D, Adams M. (2007), «Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support on non-stimulated human lymphocytes.», Austr. J. Med. Herbal., 19: 108-111

[pmid_=_12470439-5] Ng ML, Yap AT. (2002), «Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes).», National University of Singapore, J Altern Complement Med., 8 (5): 581–9, PMID 12470439, doi:10.1089/107555302320825093

[pmid_=_18670743-6] Yang P, Liang M, Zhang Y, Shen B. (2008), «Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.», Adv Ther., 25 (8): 787–94, PMID 18670743, doi:10.1007/s12325-008-0079-x

[pmid_=_16897983-7] Nimura H, Mitsumori N, Takahashi N, (2006), «[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]», Gan to Kagaku Ryoho., 33 (1): 106–9, PMID 16897983

[pmid_=_10522061-8] Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999), «A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.», Hepatogastroenterology., 46 (28): 2662–8, PMID 10522061

[pmid19596954-9] Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (2009). «Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer». Anticancer Res. 29 (7): 2739–45. PMID 19596954

[pmid19596936-10] Hazama S, Watanabe S, Ohashi M; et al. (2009). «Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer». Anticancer Res. 29 (7): 2611–7. PMID 19596936

[pmid19579640-11] Kataoka H, Shimura T, Mizoshita T; et al. (2009). «Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life». Hepatogastroenterology. 56 (90): 547–50. PMID 19579640

[pmid19579616-12] Isoda N, Eguchi Y, Nukaya H; et al. (2009). «Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma». Hepatogastroenterology. 56 (90): 437–41. PMID 19579616

[pmid19453066-13] Shimizu K, Watanabe S, Watanabe S; et al. (2009). «Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer». Hepatogastroenterology. 56 (89): 240–4. PMID 19453066

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]