LIMSwiki

OAS2
Identifiers
AliasesOAS2, 2'-5'-oligoadenylate synthetase 2
External IDsOMIM: 603350; MGI: 2180852; HomoloGene: 49478; GeneCards: OAS2; OMA:OAS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032731
NM_002535
NM_016817

NM_145227
NM_001347448

RefSeq (protein)

NP_001027903
NP_002526
NP_058197

NP_001334377
NP_660262

Location (UCSC)Chr 12: 112.98 – 113.01 MbChr 5: 120.87 – 120.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[5][6]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111335Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032690Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–277. doi:10.1006/geno.1998.5443. PMID 9790745.
  6. ^ a b "Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa".

Further reading