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T-0156
Names
	Preferred IUPAC name Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-[(pyrimidin-2-yl)methoxy]-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate
	Other names T0156
Identifiers
CAS Number	324572-93-2 [IUPHAR];
3D model (JSmol)	Interactive image; (HCl): Interactive image;
ChEBI	CHEBI:93111;
ChEMBL	ChEMBL1190161; (HCl): ChEMBL540294;
ChemSpider	5175; (HCl): 8027754;
IUPHAR/BPS	5275;
PubChem CID	5368; (HCl): 9852041;
CompTox Dashboard (EPA)	DTXSID701045745 ;
	InChI InChI=1S/C31H29N5O7/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24/h6-15H,16-17H2,1-5H3 Key: JEMJAABFSYOLAP-UHFFFAOYSA-N; (HCl): InChI=1S/C31H29N5O7.ClH/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24;/h6-15H,16-17H2,1-5H3;1H Key: RBJCBXAXUHCWBR-UHFFFAOYSA-N;
	SMILES CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC; (HCl): CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl;
Properties
Chemical formula	C31H29N5O7
Molar mass	583.601 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

T-0156 is a phosphodiesterase 5 inhibitor.^[1]^[2]

References

^ Parlak, A; Yildirim, S; Bagcivan, I; Durmus, N (October 2012). "Role of New Agents Affecting NO/cGMP Pathway on Ovalbumin-Sensitized Guinea Pig Trachea". Experimental Lung Research. 38 (8): 420–6. doi:10.3109/01902148.2012.719281. PMID 23030645. S2CID 22720639.
^ Santos, AI; Carreira, BP; Nobre, RJ; Carvalho, CM; Araújo, IM (2014). "Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5". Stem Cells International. 2014: 878397. doi:10.1155/2014/878397. PMC 3914480. PMID 24550991.

[1] Parlak, A; Yildirim, S; Bagcivan, I; Durmus, N (October 2012). "Role of New Agents Affecting NO/cGMP Pathway on Ovalbumin-Sensitized Guinea Pig Trachea". Experimental Lung Research. 38 (8): 420–6. doi:10.3109/01902148.2012.719281. PMID 23030645. S2CID 22720639.

[2] Santos, AI; Carreira, BP; Nobre, RJ; Carvalho, CM; Araújo, IM (2014). "Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5". Stem Cells International. 2014: 878397. doi:10.1155/2014/878397. PMC 3914480. PMID 24550991.

[1]

[2]

Phosphodiesterase inhibitors
PDE1	MMPX SCH-51866 Vinpocetine
PDE2	BAY 60-7550 Carbazeran EHNA Oxindole PDP
PDE3	Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine Carbazeran Cilostamide Cilostazol Enoximone Ensifentrine Imazodan KMUP-1 Meribendan Milrinone Olprinone Parogrelil Pimobendan Pumafentrine Quazinone RPL-554 Siguazodan Trequinsin Vesnarinone Zardaverine
PDE4	Apremilast Arofylline Atizoram Benafentrine Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline Crisaborole Denbutylline Difamilast Drotaverine Ensifentrine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Lotamilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Pumafentrine Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 Tetomilast Tofimilast YM-976 Zardaverine
PDE5	Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil
PDE7	BRL-50481
PDE9	BAY 73-6691 PF-04447943 Paraxanthine
PDE10	Balipodect Mardepodect MK-8189 Papaverine TC-E 5005 Tofisopam
PDE11	BC11-38
Non-selective	Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Pentoxifylline Propentofylline Theobromine Theophylline Zaprinast
Unsorted	Diazepam Diprophylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Pentifylline Proxyphylline Quercetin Satigrel Tolafentrine Trapidil
See also: Receptor/signaling modulators