The US FDA’s proposed rule on laboratory-developed tests: Impacts on clinical laboratory testing

Aerial view of Presque Isle toward the east-northeast

Presque Isle State Park (/prɛsk/ PRESK) is a 3,112-acre (1,259 ha) Pennsylvania State Park on an arching, sandy peninsula jutting into Lake Erie, 4 miles (6 km) west of the city of Erie, in Millcreek Township, Erie County, Pennsylvania, in the United States. The peninsula sweeps northeastward, surrounding Presque Isle Bay along the park's southern coast. It has 13 miles (21 km) of roads, 21 miles (34 km) of recreational trails, 13 beaches for swimming, and a marina. Popular activities at the park include swimming, boating, hiking, biking, and birdwatching.

The recorded history of Presque Isle begins with the Erielhonan, a Native American tribe who gave their name to Lake Erie, and includes French, British, and American forts, as well as serving as a base for Commodore Oliver Hazard Perry's fleet in the War of 1812. With the growing importance of shipping on Lake Erie in the 19th century, Presque Isle became home to several lighthouses and what later became a United States Coast Guard station. In 1921, it became a state park, and as of 2007 it hosts over 4 million visitors per year, the most of any Pennsylvania state park. (Full article...)

Altoona seen from Brush Mountain in September 2011

Altoona (/ælˈtuːnə/ al-TOO-nə) is a city in Blair County, Pennsylvania, United States. The population was 43,963 at the time of the 2020 census. It is the principal city of the Altoona metropolitan area, which includes all of Blair County and was recorded as having a population of 122,823.

Altoona was established in 1849 by the Pennsylvania Railroad. Having grown around the railroad industry, the city has worked to recover from industrial decline and urban decentralization experienced in recent decades. The city is home to the Altoona Curve baseball team of the Eastern League, which is the AA affiliate of the Pittsburgh Pirates Major League Baseball team. They play at Peoples Natural Gas Field in Altoona. The Altoona Symphony Orchestra has called Altoona home since 1928. Prominent landmarks include the Horseshoe Curve, the Railroaders Memorial Museum, the Juniata Shops of the Altoona Works, the Mishler Theatre, the Cathedral of the Blessed Sacrament, and the Jaffa Shrine Center. (Full article...)

• ... that unlike most hotels from the same period, the Eagle Hotel (pictured), built in 1826 in Waterford, Pennsylvania, has quoining?
• ... that Anthony Sadowski, after escaping captivity in the Great Northern War in 1704, came to America and helped Daniel Boone's father found Amity Township, Pennsylvania?
• ... that the State of Pennsylvania and its twin sister, the State of Delaware, were both the first steamboats to make a live radio broadcast and to show movies?
• ... that in 2001, James Hedges of Thompson Township, Fulton County, Pennsylvania, became the first Prohibition Party member elected in a partisan election since 1959?
• ... that the Sturgeon House in Fairview is a rare example of a saltbox house in northwestern Pennsylvania?

Randolph Frederick Pausch (/paʊʃ/) (October 23, 1960 – July 25, 2008) was an American educator, a professor of computer science, human–computer interaction, and design at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania.

Pausch learned he had pancreatic cancer in September 2006. In August 2007, he was given a terminal diagnosis: "three to six months of good health left". He gave an upbeat lecture titled, "The Last Lecture: Really Achieving Your Childhood Dreams" on September 18, 2007 at Carnegie Mellon, which became a popular YouTube video and led to other media appearances. He co-authored a book of the same name, The Last Lecture, which became a New York Times best-seller. (Full article...)

An Amish family riding in a traditional Amish buggy in Lancaster County, Pennsylvania

The Amish (/ˈɑːmɪʃ/ ^ⓘ, also /ˈæmɪʃ/ or /ˈeɪmɪʃ/; Pennsylvania German: Amisch; German: Amische), formally the Old Order Amish, are a group of traditionalist Anabaptist Christian church fellowships with Swiss and Alsatian origins. As they maintain a degree of separation from surrounding populations, and hold their faith in common, the Amish have been described by certain scholars as an ethnoreligious group, combining features of an ethnicity and a Christian denomination. The Amish are closely related to Old Order Mennonites and Conservative Mennonites, denominations that are also a part of Anabaptist Christianity. The Amish are known for simple living, plain dress, Christian pacifism, and slowness to adopt many conveniences of modern technology, with a view neither to interrupt family time, nor replace face-to-face conversations whenever possible, and a view to maintain self-sufficiency. The Amish value rural life, manual labor, humility and Gelassenheit (submission to God's will).

The Amish church began with a schism in Switzerland within a group of Swiss and Alsatian Mennonite Anabaptists in 1693 led by Jakob Ammann. Those who followed Ammann became known as Amish. In the second half of the 19th century, the Amish divided into Old Order Amish and Amish Mennonites; the latter do not abstain from using motor cars, whereas the Old Order Amish retained much of their traditional culture. When people refer to the Amish today, they normally refer to the Old Order Amish, though there are other subgroups of Amish. The Amish fall into three main subgroups—the Old Order Amish, the New Order Amish, and the Beachy Amish—all of whom wear plain dress and live their life according to the Bible as codified in their church's Ordnung. The Old Order Amish and New Order Amish conduct their worship in German, speak Pennsylvania Dutch, and use buggies for transportation, in contrast to the Beachy Amish who use modern technology (inclusive of motor cars) and conduct worship in the local language of the area in which they reside. Both the New Order Amish and the Beachy Amish emphasize the New Birth, evangelize to seek converts, and have Sunday Schools. (Full article...)

• November 2: On the campaign trail in the USA, October 2020
• October 29: On the campaign trail in the USA, September 2020
• September 30: On the campaign trail in the USA, August 2020
• August 31: On the campaign trail in the USA, July 2020
• November 21: Slippery business: Materials scientists invent new coating for self-cleaning, water-efficient toilets