The US FDA’s proposed rule on laboratory-developed tests: Impacts on clinical laboratory testing
For the Super NES enhancement chip see List of Super NES enhancement chips
| |
| Names | |
|---|---|
| Preferred IUPAC name
N-[(2-Bromophenyl)methyl]-2-chloro-N-ethylethan-1-amine | |
| Identifiers | |
3D model (JSmol)
|
|
| ChemSpider | |
PubChem CID
|
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C11H15BrClN | |
| Molar mass | 276.60 g/mol |
| Density | 1.339 g/cm3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a monoaminergic neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.[1]
It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.[2]
See also
References
- ^ Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation". J. Neurosci. 5 (7): 1925–1933. doi:10.1523/jneurosci.05-07-01925.1985. PMC 6565098. PMID 3926960.
- ^ Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats". Brain Res. 188 (2): 513–523. doi:10.1016/0006-8993(80)90049-9. PMID 7370771. S2CID 36955590.
