Sigma metrics as a valuable tool for effective analytical performance and quality control planning in the clinical laboratory: A retrospective study
Introduction
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of at least one cell that processes hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments.
Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations. Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the scientific method to make observations, pose questions, generate hypotheses, perform experiments, and form conclusions about the world around them.
Life on Earth, which emerged more than 3.7 billion years ago, is immensely diverse. Biologists have sought to study and classify the various forms of life, from prokaryotic organisms such as archaea and bacteria to eukaryotic organisms such as protists, fungi, plants, and animals. These various organisms contribute to the biodiversity of an ecosystem, where they play specialized roles in the cycling of nutrients and energy through their biophysical environment. (Full article...)
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Anatomy (from Ancient Greek ἀνατομή (anatomḗ) 'dissection') is the branch of morphology concerned with the study of the internal structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having its beginnings in prehistoric times. Anatomy is inherently tied to developmental biology, embryology, comparative anatomy, evolutionary biology, and phylogeny, as these are the processes by which anatomy is generated, both over immediate and long-term timescales. Anatomy and physiology, which study the structure and function of organisms and their parts respectively, make a natural pair of related disciplines, and are often studied together. Human anatomy is one of the essential basic sciences that are applied in medicine, and is often studied alongside physiology.
Anatomy is a complex and dynamic field that is constantly evolving as discoveries are made. In recent years, there has been a significant increase in the use of advanced imaging techniques, such as MRI and CT scans, which allow for more detailed and accurate visualizations of the body's structures. (Full article...)
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Major topics
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Linus Carl Pauling FRS (/ˈpɔːlɪŋ/ PAW-ling; February 28, 1901 – August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger, and Karl Barry Sharpless). Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie.
Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure. Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of Rosalind Franklin, James Watson, Francis Crick, and Maurice Wilkins on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms. (Full article...)
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Frontispiece to a 1644 version of the expanded and illustrated edition of Historia Plantarum, originally written by Theophrastus around 300 BCE (from History of biology) -
Statue of Robert Koch in Berlin. Koch directly provided proof for the germ theory of diseases, therefore creating the scientific basis of public health, saving millions of lives. For his life's work Koch is seen as one of the founders of modern medicine. (from History of biology) -
Carefully engineered strains of the bacterium Escherichia coli are crucial tools in biotechnology as well as many other biological fields. (from History of biology) -
Wendell Stanley's crystallization of tobacco mosaic virus as a pure nucleoprotein in 1935 convinced many scientists that heredity might be explained purely through physics and chemistry. (from History of biology) -
Thomas Hunt Morgan discovered sex linked inheritance of the white eyed mutation in the fruit fly Drosophila in 1910, implying the gene was on the sex chromosome. (from History of genetics) -
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Aristotle's model of transmission of movements from parents to child, and of form from the father. The model is not fully symmetric. (from History of genetics) -
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In Micrographia, Robert Hooke had applied the word cell to biological structures such as this piece of cork, but it was not until the 19th century that scientists considered cells the universal basis of life. (from History of biology) -
A biomedical work by Ibn al-Nafis, an early adherent of experimental dissection who discovered the pulmonary and coronary circulation (from History of biology) -
Charles Darwin's first sketch of an evolutionary tree from his First Notebook on Transmutation of Species (1837) (from History of biology) -
De arte venandi, by Frederick II, Holy Roman Emperor, was an influential medieval natural history text that explored bird morphology. (from History of biology) -
Efforts are made to preserve the natural characteristics of Hopetoun Falls, Australia, without affecting visitors' access. (from Conservation biology) -
Clay models of animal livers dating between the nineteenth and eighteenth centuries BCE, found in the royal palace at Mari (from History of biology) -
Penicillin was viewed as a miracle drug that brought enormous profits and public expectations. (from History of biotechnology) -
The "central dogma of molecular biology" (originally a "dogma" only in jest) was proposed by Francis Crick in 1958. This is Crick's reconstruction of how he conceived of the central dogma at the time. The solid lines represent (as it seemed in 1958) known modes of information transfer, and the dashed lines represent postulated ones. (from History of biology) -
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The frontispiece to Erasmus Darwin's evolution-themed poem The Temple of Nature shows a goddess pulling back the veil from nature (in the person of Artemis). Allegory and metaphor have often played an important role in the history of biology. (from History of biology) -
Diagram of Charles Darwin's pangenesis theory. Every part of the body emits tiny particles, gemmules, which migrate to the gonads and contribute to the fertilised egg and so to the next generation. The theory implied that changes to the body during an organism's life would be inherited, as proposed in Lamarckism. (from History of genetics) -
More conservation research is needed for understanding ecology and behaviour of the dhole in central China. (from Conservation biology) -
An art scape image showing the relative importance of animals in a rain forest through a summary of (a) child's perception compared with (b) a scientific estimate of the importance. The size of the animal represents its importance. The child's mental image places importance on big cats, birds, butterflies, and then reptiles versus the actual dominance of social insects (such as ants). (from Conservation biology) -
Summary of 2006 IUCN Red List categories: EX (Extinct) — EW (Extinct in the Wild) — CR (Critically Endangered) — EN (Endangered) — VU (Vulnerable) — NT (Near Threatened) — LC (Least Concern) (from Conservation biology) -
A pie chart image showing the relative biomass representation in a rain forest through a summary of children's perceptions from drawings and artwork (left), through a scientific estimate of actual biomass (middle), and by a measure of biodiversity (right). The biomass of social insects (middle) far outweighs the number of species (right). (from Conservation biology) -
A Genentech-sponsored sign declaring South San Francisco to be "The Birthplace of Biotechnology." (from History of biotechnology) -
Innovative laboratory glassware and experimental methods developed by Louis Pasteur and other biologists contributed to the young field of bacteriology in the late 19th century. (from History of biology) -
Blending Inheritance (from History of genetics) -
Some biodiversity loss is more insidious than others due to systemic neglect. For example, sport killing and wanton waste of tons of native fishes from unregulated 21st century bowfishing in the United States. New conservation movements are needed to deter irreparable biodiversity loss to fragile freshwater ecosystems. (from Conservation biology) -
August Weismann's germ plasm theory. The hereditary material, the germ plasm, is confined to the gonads. Somatic cells (of the body) develop afresh in each generation from the germ plasm. (from History of genetics) -
Mendelian inheritance states characteristics are discrete and are inherited by the parents. This image depicts a monohybrid cross and shows 3 generations: P1 generation (1), F1 generation (2), and F2 generation (3). Each organism inherits two alleles, one from each parent, that make up the genotype. The observed characteristic, the phenotype, is determined by the dominant allele in the genotype. In this monohybrid cross the dominant allele encodes for the colour red and the recessive allele encodes for the colour white. (from History of genetics) -
Thomas Hunt Morgan's illustration of crossing over, part of the Mendelian-chromosome theory of heredity (from History of biology) -
Synthetic insulin crystals synthesized using recombinant DNA technology (from History of biotechnology) -
Inside of a 48-well thermal cycler, a device used to perform polymerase chain reaction on many samples at once (from History of biology) -
2016 conservation indicator which includes the following indicators: marine protected areas, terrestrial biome protection (global and national), and species protection (global and national) (from Conservation biology) -
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Gregor Mendel, "father of modern genetics" (from History of biology) -
Description of rare animals (写生珍禽图), by Huang Quan (903–965) during the Song dynasty (from History of biology) -
Brewing was an early example of biotechnology (from History of biotechnology) -
Cabinets of curiosities, such as that of Ole Worm, were centers of biological knowledge in the early modern period, bringing organisms from across the world together in one place. Before the Age of Exploration, naturalists had little idea of the sheer scale of biological diversity. (from History of biology) -
In the course of his travels, Alexander von Humboldt mapped the distribution of plants across landscapes and recorded a variety of physical conditions such as pressure and temperature. (from History of biology)
Did you know -
- ... that the p19 protein (dimer pictured) evolved in an arms race between plants and viruses?
- ...that there are about a million nephrons in a human kidney?
- ... that the semi-aquatic grasshopper Cornops aquaticum is being trialled in South Africa as a biological control agent for the invasive water hyacinth?
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