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Lopirazepam
Clinical data
Pregnancy
category
  • D
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • (RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-pyrido[3,2-e][1,4]diazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.050.868 Edit this at Wikidata
Chemical and physical data
FormulaC14H9Cl2N3O2
Molar mass322.15 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • ClC1=CC=CC=C1C2=NC(C(NC3=C2N=C(Cl)C=C3)=O)O

Lopirazepam (INN)[1] is a short-acting benzodiazepine analog of the pyridodiazepine type (specifically, the pyridodiazepine analog of lorazepam) with anxiolytic and hypnotic properties.[2][3] It has never been marketed.[4]

See also

References

  1. ^ US 4008223, von Bebenburg W, Offermanns H, "6-Aza-3H-1,4-benzodiazepines", issued 15 February 1977, assigned to Deutsche Gold und Silber Scheideanstalt and Evonik Operations GmbH. 
  2. ^ Saletu M, Saletu B, Grünberger J, Mader R, Karobath M (1983). "Clinical symptomatology and computer analyzed EEG before, during and after anxiolytic therapy of alcohol withdrawal patients". Neuropsychobiology. 9 (2–3): 119–134. doi:10.1159/000117949. PMID 6353268.
  3. ^ Fabian A, Röhmel R, Kubicki S (September 1984). "[Changes in the length of sleep cycles during administration of flurazepam and lopirazepam]". EEG-EMG Zeitschrift für Elektroenzephalographie, Elektromyographie und Verwandte Gebiete (in German). 15 (3): 151–158. PMID 6435999.
  4. ^ Triggle DJ, Ganellin CR, MacDonald F (1996). Dictionary of Pharmacological Agents. Vol. 2. Boca Raton: Chapman & Hall/CRC. p. 1232. ISBN 0-412-46630-9. Retrieved on December 31, 2008 through Google Book Search.