Risk assessment of over-the-counter cannabinoid-based cosmetics: Legal and regulatory issues governing the safety of cannabinoid-based cosmetics in the UAE

'''Integrin alpha-IIb''' is a [[protein]] that in humans is encoded by the ''ITGA2B'' [[gene]].

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| summary_text = ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.<ref>{{cite web | title = Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3674| accessdate = }}</ref>

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ITGA2B has been shown to [[Protein-protein interaction|interact]] with [[AUP1]]<ref name=pmid12042322>{{cite journal |last=Kato |first=Atsushi |authorlink= |author2=Kawamata Norihiko |author3=Tamayose Kenji |author4=Egashira Motoki |author5=Miura Rika |author6=Fujimura Tsutomu |author7=Murayama Kimie |author8=Oshimi Kazuo |date=Aug 2002 |title=Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28934–41 |publisher= |location = United States| issn = 0021-9258| pmid = 12042322 |doi = 10.1074/jbc.M204340200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[CLNS1A]].<ref name=pmid15075326>{{cite journal |last=Larkin |first=Deirdre |authorlink= |author2=Murphy Derek |author3=Reilly Dermot F |author4=Cahill Martha |author5=Sattler Ellen |author6=Harriott Pat |author7=Cahill Dolores J |author8=Moran Niamh |date=Jun 2004 |title=ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation |journal=J. Biol. Chem. |volume=279 |issue=26 |pages=27286–93 |publisher= |location = United States| issn = 0021-9258| pmid = 15075326 |doi = 10.1074/jbc.M402159200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

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| citations =

*{{cite journal | author=Bray PF |title=Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization. |journal=Thromb. Haemost. |volume=72 |issue= 4 |pages= 492–502 |year= 1995 |pmid= 7878622 |doi= }}

*{{cite journal | author=Naik UP, Parise LV |title=Structure and function of platelet alpha IIb beta 3. |journal=Curr. Opin. Hematol. |volume=4 |issue= 5 |pages= 317–22 |year= 1997 |pmid= 9288464 |doi= }}

*{{cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=10.1016/S0962-8924(98)01344-0 }}

*{{cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 340–54 |year= 2001 |pmid= 11460491 |doi=10.1111/j.1749-6632.2001.tb03521.x }}

*{{cite journal |vauthors=Plow EF, Cierniewski CS, Xiao Z, etal |title=AlphaIIbbeta3 and its antagonism at the new millennium. |journal=Thromb. Haemost. |volume=86 |issue= 1 |pages= 34–40 |year= 2002 |pmid= 11487023 |doi= }}

*{{cite journal |vauthors=Quinn MJ, Byzova TV, Qin J, etal |title=Integrin alphaIIbbeta3 and its antagonism. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 945–52 |year= 2004 |pmid= 12637342 |doi= 10.1161/01.ATV.0000066686.46338.F1 }}

*{{cite journal | author=Watson SP, Auger JM, McCarty OJ, Pearce AC |title=GPVI and integrin alphaIIb beta3 signaling in platelets. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1752–62 |year= 2005 |pmid= 16102042 |doi= 10.1111/j.1538-7836.2005.01429.x }}

*{{cite journal | author=Ma YQ, Qin J, Plow EF |title=Platelet integrin alpha(IIb)beta(3): activation mechanisms. |journal=J. Thromb. Haemost. |volume=5 |issue= 7 |pages= 1345–52 |year= 2007 |pmid= 17635696 |doi= 10.1111/j.1538-7836.2007.02537.x }}

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{{PDB Gallery|geneid=3674}}

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