Potency and safety analysis of hemp-derived delta-9 products: The hemp vs. cannabis demarcation problem

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  • [1-(Cyclohexylmethyl)-1H-indol-3-yl](naphthalen-1-yl)methanone
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass367.492 g·mol−1
3D model (JSmol)
  • O=C(c1cccc2ccccc12)c3cn(CC4CCCCC4)c5ccccc35
  • InChI=1S/C26H25NO/c28-26(23-15-8-12-20-11-4-5-13-21(20)23)24-18-27(17-19-9-2-1-3-10-19)25-16-7-6-14-22(24)25/h4-8,11-16,18-19H,1-3,9-10,17H2

NE-CHMIMO (CHM-018) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1][2][3] NE-CHMIMO is the 1-cyclohexylmethyl (instead of 1-pentyl) analogue of the first-generation synthetic cannabinoid JWH-018. The corresponding cyclohexylmethyl derivative of JWH-081 had also been reported several months earlier.[4]

Legal status

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as NE-CHMIMO are Schedule I Controlled Substances.[5]

NE-CHMIMO is a controlled substance in Japan as of November 2019.[6]

See also


  1. ^ Angerer V, Bisel P, Moosmann B, Westphal F, Auwärter V (September 2016). "Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative "NE-CHMIMO" using flash chromatography, GC-MS, IR and NMR spectroscopy". Forensic Science International. 266: e93–e98. doi:10.1016/j.forsciint.2016.05.031. PMID 27297324.
  2. ^ Franz F, Jechle H, Angerer V, Pegoro M, Auwärter V, Neukamm MA (May 2018). "Synthetic cannabinoids in hair - Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples". Analytica Chimica Acta. 1006: 61–73. doi:10.1016/j.aca.2017.12.029. PMID 30016265.
  3. ^ "NE-CHMIMO". New Synthetic Drugs Database.
  4. ^ Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J (March 2016). "Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense". Forensic Science International. 260: 40–53. doi:10.1016/j.forsciint.2015.12.001. PMID 26795397.
  5. ^ 21 U.S.C. § 812: Schedules of controlled substances
  6. ^ "指定薬物を指定する省令が公布されました|厚生労働省". www.mhlw.go.jp (in Japanese). Ministry of Health, Labour and Welfare. Retrieved 2019-12-22.