Potency and safety analysis of hemp-derived delta-9 products: The hemp vs. cannabis demarcation problem

Edit links
Legal status
Legal status
  • (1-Pentyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone
CAS Number
PubChem CID
Chemical and physical data
Molar mass369.508 g·mol−1
3D model (JSmol)
  • CCCCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=C3C=C(C=C4)C)C
  • InChI=1S/C26H27NO/c1-4-5-8-16-27-19(3)25(22-11-6-7-13-24(22)27)26(28)21-12-9-10-20-15-14-18(2)17-23(20)21/h6-7,9-15,17H,4-5,8,16H2,1-3H3

JWH-048 is a selective cannabinoid ligand, with a bindining affinity of Ki = 0.5 ± 0.1 nM for the CB2 subtype, and more than 22 times selectivity over the CB1.[1]

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-048 are Schedule I Controlled Substances.[2]

See also


  1. ^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.
  2. ^ 21 U.S.C. § 812: Schedules of controlled substances