Protein-coding gene in the species Homo sapiens
Rh family, B glycoprotein , also known as RHBG , is an ammonia transporter protein which in humans is encoded by the RHBG gene .[ 5] [ 6]
Function
RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.[ 5]
References
Further reading
Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues". Blood Cells Mol. Dis . 27 (1): 90–101. doi :10.1006/bcmd.2000.0355 . PMID 11358367 . Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis" . J. Biol. Chem . 275 (33): 25641–51. doi :10.1074/jbc.M003353200 PMID 10852913 . Liu Z, Peng J, Mo R, et al. (2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals" . J. Biol. Chem . 276 (2): 1424–33. doi :10.1074/jbc.M007528200 PMID 11024028 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ludewig U (2005). "Electroneutral ammonium transport by basolateral rhesus B glycoprotein" . J. Physiol . 559 (Pt 3): 751–9. doi :10.1113/jphysiol.2004.067728 . PMC 1665183 PMID 15284342 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Lopez C, Métral S, Eladari D, et al. (2005). "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells" . J. Biol. Chem . 280 (9): 8221–8. doi :10.1074/jbc.M413351200 PMID 15611082 . Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells" . Biochem. J . 391 (Pt 1): 33–40. doi :10.1042/BJ20050657 . PMC 1237136 PMID 15929723 . Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins" . Proc. Natl. Acad. Sci. U.S.A . 102 (43): 15512–7. Bibcode :2005PNAS..10215512H . doi :10.1073/pnas.0507886102 PMC 1266151 PMID 16227429 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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