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Kalcineurin je heterodimer od 61-kD kalmodulin-vezujuće katalitičke podjedinice, kalcineurina A i 19-kD Ca2+-vezujuće regulatorne podjedinice, kalcineurina B. Postoje tri izozima katalitčke podjedinice, svaka od kojih je kodirana zasebnim genom (PPP3CA, PPP3CB, i PPP3CC) i dve regulatorne izoforme, takođe kodirane zasebnim genima (PPP3R1, PPP3R2).
^PDB: 1AUI; Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW (1995). „Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex”. Nature. 378 (6557): 641—4. PMID8524402. doi:10.1038/378641a0.
^Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (2005). „Crystal Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis”. Mol Biol Rep. 32 (1): 41—45. PMID15865209. doi:10.1007/s11033-004-4250-4.
Literatura
Crabtree GR (1999). „Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT”. Cell. 96 (5): 611—4. PMID10089876. doi:10.1016/S0092-8674(00)80571-1.
Giri PR, Higuchi S, Kincaid RL (1992). „Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit”. Biochem. Biophys. Res. Commun. 181 (1): 252—8. PMID1659808. doi:10.1016/S0006-291X(05)81410-X.
Kincaid RL; Giri PR; Higuchi S; et al. (1990). „Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods”. J. Biol. Chem. 265 (19): 11312—9. PMID2162844.CS1 одржавање: Експлицитна употреба et al. (веза)
Coghlan VM; Perrino BA; Howard M; et al. (1995). „Association of protein kinase A and protein phosphatase 2B with a common anchoring protein”. Science. 267 (5194): 108—11. PMID7528941. doi:10.1126/science.7528941.CS1 одржавање: Експлицитна употреба et al. (веза)
Griffith JP; Kim JL; Kim EE; et al. (1995). „X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex”. Cell. 82 (3): 507—22. PMID7543369. doi:10.1016/0092-8674(95)90439-5.CS1 одржавање: Експлицитна употреба et al. (веза)
Muramatsu T, Kincaid RL (1993). „Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)”. Biochim. Biophys. Acta. 1178 (1): 117—20. PMID8392375. doi:10.1016/0167-4889(93)90117-8.
Cameron AM; Steiner JP; Roskams AJ; et al. (1996). „Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux”. Cell. 83 (3): 463—72. PMID8521476. doi:10.1016/0092-8674(95)90124-8.CS1 одржавање: Експлицитна употреба et al. (веза)
Kissinger CR; Parge HE; Knighton DR; et al. (1996). „Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex”. Nature. 378 (6557): 641—4. PMID8524402. doi:10.1038/378641a0.CS1 одржавање: Експлицитна употреба et al. (веза)
Wang MG; Yi H; Guerini D; et al. (1997). „Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively”. Cytogenet. Cell Genet. 72 (2–3): 236—41. PMID8978785. doi:10.1159/000134198.CS1 одржавање: Експлицитна употреба et al. (веза)
Shibasaki F, Kondo E, Akagi T, McKeon F (1997). „Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2”. Nature. 386 (6626): 728—31. PMID9109491. doi:10.1038/386728a0.
Kashishian A; Howard M; Loh C; et al. (1998). „AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region”. J. Biol. Chem. 273 (42): 27412—9. PMID9765270. doi:10.1074/jbc.273.42.27412.CS1 одржавање: Експлицитна употреба et al. (веза)
Wang HG; Pathan N; Ethell IM; et al. (1999). „Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD”. Science. 284 (5412): 339—43. PMID10195903. doi:10.1126/science.284.5412.339.CS1 одржавање: Експлицитна употреба et al. (веза)
Fuentes JJ; Genescà L; Kingsbury TJ; et al. (2000). „DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways”. Hum. Mol. Genet. 9 (11): 1681—90. PMID10861295. doi:10.1093/hmg/9.11.1681.CS1 одржавање: Експлицитна употреба et al. (веза)
Siddiq A; Miyazaki T; Takagishi Y; et al. (2001). „Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism”. Endocrinology. 142 (5): 1752—9. PMID11316738. doi:10.1210/en.142.5.1752.CS1 одржавање: Експлицитна употреба et al. (веза)
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