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Purinski receptor P2Y, G-protein spregnuti, 1
Purinski receptor P2Y, G-protein spregnuti, 1
Identifikatori
Simboli	P2RY1; P2Y1
Vanjski ID	OMIM: 601167 MGI: 105049 HomoloGene: 1926 IUPHAR: P2Y1 GeneCards: P2RY1 Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • receptorska aktivnost; • purinska nukleotidna receptorska aktivnost, GPCR;
Celularna komponenta	• integralno sa membranom plazme; • membrana;
Biološki proces	• G-protein signalizacija, spregnuta sa IP3 drugim glasnikom (aktivacija fosfolipaze C); • koagulacija krvi;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5028
Ensembl	ENSG00000169860
UniProt	P47900
RefSeq (mRNA)	NM_002563
RefSeq (protein)	NP_002554
Lokacija (UCSC)	Chr 3:; 154.04 - 154.04 Mb
PubMed pretraga	[1]

P2Y purinoceptor 1 je protein koji kod je kod ljudi kodiran P2RY1 genom.^[1]

Produkt ovog gena, P2Y₁ pripada P2Y familiji GPCR receptora. Ta familija ima nekoliko receptorskih podtipova sa različitom farmakološkom selektivnošću. Ovaj receptor funkcioniše kao receptor za ekstracelularni ATP i ADP. U trombocitima ADP vezivanje dovodi do mobilizacije intracelularnih jona kalcijuma putem aktivacije fosfolipaze C, promene oblika trombocita, i verovatno doprinosi njihovoj agregaciji.^[2]

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P2Y receptor

Literatura

^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (1996). „Cloning and chromosomal localization of the human P2Y1 purinoceptor”. Biochem Biophys Res Commun. 218 (3): 783—8. PMID 8579591. doi:10.1006/bbrc.1996.0139.
^ „Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1”.

Dodatna literatura

Janssens R; Communi D; Pirotton S; et al. (1996). „Cloning and tissue distribution of the human P2Y1 receptor.”. Biochem. Biophys. Res. Commun. 221 (3): 588—93. PMID 8630005. doi:10.1006/bbrc.1996.0640.
Léon C, Vial C, Cazenave JP, Gachet C (1996). „Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.”. Gene. 171 (2): 295—7. PMID 8666290. doi:10.1016/0378-1119(96)00027-3.
Léon C; Hechler B; Vial C; et al. (1997). „The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.”. FEBS Lett. 403 (1): 26—30. PMID 9038354. doi:10.1016/S0014-5793(97)00022-7.
Ayyanathan K, Naylor SL, Kunapuli SP (1997). „Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1).”. Somat. Cell Mol. Genet. 22 (5): 419—24. PMID 9039850. doi:10.1007/BF02369897.
Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297—302. PMID 9268704. doi:10.1006/bbrc.1997.7135.
Jin J, Daniel JL, Kunapuli SP (1998). „Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.”. J. Biol. Chem. 273 (4): 2030—4. PMID 9442040. doi:10.1074/jbc.273.4.2030.
Hall RA; Ostedgaard LS; Premont RT; et al. (1998). „A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.”. Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496—501. PMC 21104 . PMID 9671706. doi:10.1073/pnas.95.15.8496.
Sabala P; Czajkowski R; Przybyłek K; et al. (2001). „Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.”. Br. J. Pharmacol. 132 (2): 393—402. PMC 1572584 . PMID 11159687. doi:10.1038/sj.bjp.0703843.
Yoshioka K, Saitoh O, Nakata H (2001). „Heteromeric association creates a P2Y-like adenosine receptor.”. Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7617—22. PMC 34717 . PMID 11390975. doi:10.1073/pnas.121587098.
James G, Butt AM (2001). „Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.”. Neurosci. Lett. 312 (1): 33—6. PMID 11578839. doi:10.1016/S0304-3940(01)02189-9.
Moore DJ; Chambers JK; Wahlin JP; et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID 11690642.
Czajkowski R, Lei L, Sabała P, Barańska J (2002). „ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).”. FEBS Lett. 513 (2-3): 179—83. PMID 11904146. doi:10.1016/S0014-5793(02)02255-X.
Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). „Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.”. Biochem. Pharmacol. 64 (3): 433—9. PMID 12147294. doi:10.1016/S0006-2952(02)01113-9.
Nurden P; Poujol C; Winckler J; et al. (2003). „Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.”. Blood. 101 (4): 1400—8. PMID 12393588. doi:10.1182/blood-2002-02-0642.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). „Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.”. J. Invest. Dermatol. 120 (3): 440—7. PMID 12603858. doi:10.1046/j.1523-1747.2003.12050.x.
Jagroop IA, Burnstock G, Mikhailidis DP (2003). „Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.”. Platelets. 14 (1): 15—20. PMID 12623443. doi:10.1080/0953710021000062914.
Greig AV; Linge C; Terenghi G; et al. (2003). „Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.”. J. Invest. Dermatol. 120 (6): 1007—15. PMID 12787128. doi:10.1046/j.1523-1747.2003.12261.x.
Wang L; Ostberg O; Wihlborg AK; et al. (2003). „Quantification of ADP and ATP receptor expression in human platelets.”. J. Thromb. Haemost. 1 (2): 330—6. PMID 12871508. doi:10.1046/j.1538-7836.2003.00070.x.
„P2Y Receptors: P2Y₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[pmid8579591-1] Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (1996). „Cloning and chromosomal localization of the human P2Y1 purinoceptor”. Biochem Biophys Res Commun. 218 (3): 783—8. PMID 8579591. doi:10.1006/bbrc.1996.0139.

[entrez-2] „Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1”.

[1]

[2]

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