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Uvojiti receptor 3
Uvojiti receptor 3
Identifikatori
Simboli	FZD3; Fz-3
Vanjski ID	OMIM: 606143 MGI: 108476 HomoloGene: 23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	7976
Ensembl	ENSG00000104290
UniProt	A8K615
RefSeq (mRNA)	NM_017412.3
RefSeq (protein)	NP_059108.1
Lokacija (UCSC)	Chr 8:; 28.35 - 28.43 Mb
PubMed pretraga	[1]

Uvojiti-3 je protein koji je kod ljudi kodiran FZD3 genom.^[1]^[2]^[3]

Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD3 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD3 transkript je izražen u različitim tkivima. Funkcija ovog proteina nije poznata. Postoje izvesne indikacije da učestvuje u razvoju folikula dlake kod sisara.^[3]

Reference

^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (2000). „Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun. 271 (1): 8—14. PMID 10777673. doi:10.1006/bbrc.2000.2578.
^ Sala CF, Formenti E, Terstappen GC, Caricasole A (2000). „Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun. 273 (1): 27—34. PMID 10873558. doi:10.1006/bbrc.2000.2882.
^ ^а ^б „Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.

Literatura

Katoh M (2002). „GIPC gene family (Review).”. Int. J. Mol. Med. 9 (6): 585—9. PMID 12011974.
Finch PW; He X; Kelley MJ; et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770.
Wright M, Aikawa M, Szeto W, Papkoff J (1999). „Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.”. Biochem. Biophys. Res. Commun. 263 (2): 384—8. PMID 10491302. doi:10.1006/bbrc.1999.1344.
Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). „Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.”. J. Invest. Dermatol. 116 (6): 940—6. PMID 11407985. doi:10.1046/j.1523-1747.2001.01336.x.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Katsu T; Ujike H; Nakano T; et al. (2004). „The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.”. Neurosci. Lett. 353 (1): 53—6. PMID 14642436. doi:10.1016/j.neulet.2003.09.017.
Zhang Y; Yu X; Yuan Y; et al. (2005). „Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16—9. PMID 15274031. doi:10.1002/ajmg.b.30076.
Zhang Z, Henzel WJ (2005). „Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819—24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504.
Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Hashimoto R; Suzuki T; Iwata N; et al. (2005). „Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.”. Journal of neural transmission (Vienna, Austria : 1996). 112 (2): 303—7. PMID 15657645. doi:10.1007/s00702-004-0264-2.

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Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 09. 2014. г.

[pmid10777673-1] Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (2000). „Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun. 271 (1): 8—14. PMID 10777673. doi:10.1006/bbrc.2000.2578.

[pmid10873558-2] Sala CF, Formenti E, Terstappen GC, Caricasole A (2000). „Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun. 273 (1): 27—34. PMID 10873558. doi:10.1006/bbrc.2000.2882.

[entrez-3] а ^б „Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.

[1]

[2]

[3]

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Reference

Literatura

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