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Tirozinska kinaza, nereceptor, 2

PDB prikaz baziran na 1cf4.
Dostupne strukture
1CF4, 1U46, 1U4D, 1U54, 3EQP, 3EQR, 4EWH, 4HZR, 4HZS, 4ID7
Identifikatori
SimboliTNK2; ACK; ACK-1; ACK1; p21cdc42Hs
Vanjski IDOMIM: 606994 MGI: 1858308 HomoloGene: 4224 GeneCards: TNK2 Gene
EC broj2.7.11.1 2.7.10.2, 2.7.11.1
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez1018851789
EnsemblENSG00000061938ENSMUSG00000022791
UniProtQ07912O54967
Ref. Sekv. (iRNK)NM_001010938NM_001110147
Ref. Sekv. (protein)NP_001010938NP_001103617
Lokacija (UCSC)Chr 3:
195.59 - 195.64 Mb		Chr 16:
32.64 - 32.68 Mb
PubMed pretraga[1][2]

Aktivirana CDC42 kinaza 1, takođe poznata kao ACK1, je enzim koji je kod ljudi kodiran TNK2 genom.[1][2][3][4][5]

TNK2 gen kodira nereceptorsku tirozinsku kinazu, ACK1, koja se vezuje za višestruke receptorske tirozinske kinaze e.g. EGFR, MERTK, AXL, HER2 i insulinski receptor (IR). ACK1 takođe interaguje sa Cdc42Hs u njegovoj GTP-vezanoj formi i inhibira intrinzičnu i GTPaznu aktivnost Cdc42H. Vezivanje je posredovano jedistvenom sekvencom od 47 aminokiselina između C-terminusa i SH3 domena. Ovaj protein učestvuje u regulatornom mehanizmu kojim se održava GTP-vezana aktivna forma Cdc42H i koji je direktno povezan sa torozinsko fosforilacionim putem prenosa signala. Poznato je nekoliko alternativno splajsovanih transkriptnih varijanti ovog gena, ali se izražavaju samo dve varijante.[5]

Interakcije

ACK1 ili TNK2 formira interakcije sa AKT,[3] Androgenskim receptorom ili AR,[6] tumornim supresorom WWOX,[7] FYN[8] i Grb2.[9][10] ACK1 interakcije sa njegovim supstratima dovode do njihove fosforilacije na specifičnim tirozinskim ostacima. ACK1 direktno fosforiliše AKT na tirozinu 176, AR na tirosizinima 267 i 363, i WWOX na torozinu 287. Ack1-AR signalizacije takođe učestvuje u regulaciji ATM nivoaa[11]

Reference

  1. ↑ Mahajan K, Mahajan NP (August 2010). „Shepherding AKT and androgen receptor by Ack1 tyrosine kinase.”. J Cell Physiol. 224 (2): 327–23. DOI:10.1002/jcp.22162. PMID 20432460. 
  2. ↑ Manser E, Leung T, Salihuddin H, Tan L, Lim L (June 1993). „A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42”. Nature 363 (6427): 364–7. DOI:10.1038/363364a0. PMID 8497321. 
  3. ↑ 3,0 3,1 Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. (March 2010). „Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation”. PLoS ONE 5 (3): e9646. DOI:10.1371/journal.pone.0009646. PMID 20333297. 
  4. ↑ Yokoyama N, Miller WT (November 2003). „Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck”. J Biol Chem 278 (48): 47713–23. DOI:10.1074/jbc.M306716200. PMID 14506255. 
  5. ↑ 5,0 5,1 „Entrez Gene: TNK2 tyrosine kinase, non-receptor, 2”. 
  6. ↑ Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, Earp HS, Whang YE. (May 2007). „Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.”. Proc Natl Acad Sci U S A. 104 (20): 8438–43. DOI:10.1073/pnas.0700420104. PMID 17494760. 
  7. ↑ Mahajan NP, Whang YE, Mohler JL, Earp HS. (November 2005). „Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.”. Cancer Res. 65 (22): 10514–23. DOI:10.1158/0008-5472.can-05-1127. PMID 16288044. 
  8. ↑ Linseman DA, Heidenreich KA, Fisher SK (February 2001). „Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway”. J. Biol. Chem. 276 (8): 5622–8. DOI:10.1074/jbc.M006812200. PMID 11087735. 
  9. ↑ Satoh T, Kato J, Nishida K, Kaziro Y (May 1996). „Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation”. FEBS Lett. 386 (2-3): 230–4. DOI:10.1016/0014-5793(96)00449-8. PMID 8647288. 
  10. ↑ Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T (June 2001). „Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner”. Biochem. Biophys. Res. Commun. 284 (2): 470–7. DOI:10.1006/bbrc.2001.5004. PMID 11394904. 
  11. ↑ Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP. (June 2012). „Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.”. J Biol Chem. 287 (26): 22112–22. DOI:10.1074/jbc.M112.357384. PMID 22566699. 

Literatura

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  • Linseman DA, Heidenreich KA, Fisher SK (2001). „Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway”. J. Biol. Chem. 276 (8): 5622–8. DOI:10.1074/jbc.M006812200. PMID 11087735. 
  • Teo M, Tan L, Lim L, Manser E (2001). „The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors”. J. Biol. Chem. 276 (21): 18392–8. DOI:10.1074/jbc.M008795200. PMID 11278436. 
  • Kato-Stankiewicz J, Ueda S, Kataoka T, et al. (2001). „Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner”. Biochem. Biophys. Res. Commun. 284 (2): 470–7. DOI:10.1006/bbrc.2001.5004. PMID 11394904. 
  • Oda T, Muramatsu MA, Isogai T, et al. (2001). „HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells”. Biochem. Biophys. Res. Commun. 288 (5): 1078–86. DOI:10.1006/bbrc.2001.5890. PMID 11700021. 
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  • Lougheed JC, Chen RH, Mak P, Stout TJ (2004). „Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1”. J. Biol. Chem. 279 (42): 44039–45. DOI:10.1074/jbc.M406703200. PMID 15308621. 

Vanjske veze

  • TNK2 human gene location in the UCSC Genome Browser.
  • TNK2 human gene details in the UCSC Genome Browser.
source: https://sh.wikipedia.org/wiki/TNK2