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EPH receptor B1
	; PDB prikaz baziran na 2djs.
Dostupne strukture
	2DJS, 2EAO, 3ZFX
Identifikatori
Simboli	EPHB1; ELK; EPHT2; Hek6; NET
Vanjski ID	OMIM: 600600 MGI: 1096337 HomoloGene: 20936 GeneCards: EPHB1 Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost transmembranskog efrinskog receptora; • proteinsko vezivanje; • ATP veivanje;
Ćelijska komponenta	• integralna komponenta ćelijske membrane; • akson; • dendrit;
Biološki proces	• angiogeneza; • aksonsko navođenje; • peptidil-tirozinska fosforilacija;
Ortolozi

Receptor 1 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB1 genom.^[1]^[2]

Funkcija

Ephrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.^[3]^[2]

Interakcije

EPH receptor B1 formira interakcije sa GRB7,^[4] ACP1^[5] i NCK1.^[6]

Reference

↑ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (Aug 1996). „cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain”. Genomics 29 (2): 426–37. DOI:10.1006/geno.1995.9985. PMID 8666391.
↑ ^2,0 ^2,1 „Entrez Gene: EPHB1 EPH receptor B1”.
↑ „Entrez Gene: EPHB2 EPH receptor B2”.
↑ Han, Dong Cho; Shen Tang-Long; Miao Hui; Wang Bingcheng; Guan Jun-Lin (Nov 2002). „EphB1 associates with Grb7 and regulates cell migration”. J. Biol. Chem. (United States) 277 (47): 45655–61. DOI:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469.
↑ Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (Mar 1998). „Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses”. Genes Dev. (UNITED STATES) 12 (5): 667–78. DOI:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402.
↑ Stein, E; Huynh-Do U; Lane A A; Cerretti D P; Daniel T O (Jan 1998). „Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase”. J. Biol. Chem. (UNITED STATES) 273 (3): 1303–8. DOI:10.1074/jbc.273.3.1303. ISSN 0021-9258. PMID 9430661.

Literatura

Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Abrahamson DR, Robert B, Hyink DP, et al. (1998). „Origins and formation of microvasculature in the developing kidney.”. Kidney Int. Suppl. 67: S7–11. DOI:10.1046/j.1523-1755.1998.06702.x. PMID 9736245.
Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
Larose L, Gish G, Shoelson S, Pawson T (1993). „Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.”. Oncogene 8 (9): 2493–9. PMID 7689724.
Davis S, Gale NW, Aldrich TH, et al. (1994). „Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.”. Science 266 (5186): 816–9. DOI:10.1126/science.7973638. PMID 7973638.
Beckmann MP, Cerretti DP, Baum P, et al. (1994). „Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.”. EMBO J. 13 (16): 3757–62. PMC 395287. PMID 8070404.
Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). „Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.”. Mol. Immunol. 32 (16): 1197–205. DOI:10.1016/0161-5890(95)00108-5. PMID 8559144.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). „Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.”. Neuron 17 (1): 9–19. DOI:10.1016/S0896-6273(00)80276-7. PMID 8755474.
Stein E, Cerretti DP, Daniel TO (1996). „Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.”. J. Biol. Chem. 271 (38): 23588–93. DOI:10.1074/jbc.271.38.23588. PMID 8798570.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Kozlosky CJ, VandenBos T, Park L, et al. (1997). „LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.”. Cytokine 9 (8): 540–9. DOI:10.1006/cyto.1997.0199. PMID 9245480.
Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
Stein E, Huynh-Do U, Lane AA, et al. (1998). „Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.”. J. Biol. Chem. 273 (3): 1303–8. DOI:10.1074/jbc.273.3.1303. PMID 9430661.
Stein E, Lane AA, Cerretti DP, et al. (1998). „Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.”. Genes Dev. 12 (5): 667–78. DOI:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.

[pmid8666391-1] Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (Aug 1996). „cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain”. Genomics 29 (2): 426–37. DOI:10.1006/geno.1995.9985. PMID 8666391.

[entrez-2] 2,0 ^2,1 „Entrez Gene: EPHB1 EPH receptor B1”.

[3] „Entrez Gene: EPHB2 EPH receptor B2”.

[pmid12223469-4] Han, Dong Cho; Shen Tang-Long; Miao Hui; Wang Bingcheng; Guan Jun-Lin (Nov 2002). „EphB1 associates with Grb7 and regulates cell migration”. J. Biol. Chem. (United States) 277 (47): 45655–61. DOI:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469.

[pmid9499402-5] Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (Mar 1998). „Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses”. Genes Dev. (UNITED STATES) 12 (5): 667–78. DOI:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402.

[pmid9430661-6] Stein, E; Huynh-Do U; Lane A A; Cerretti D P; Daniel T O (Jan 1998). „Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase”. J. Biol. Chem. (UNITED STATES) 273 (3): 1303–8. DOI:10.1074/jbc.273.3.1303. ISSN 0021-9258. PMID 9430661.

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