Knowledge Base Wiki

ODF2
Identifiers
Aliases	ODF2, CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber of sperm tails 2
External IDs	OMIM: 602015; MGI: 1098824; HomoloGene: 1907; GeneCards: ODF2; OMA:ODF2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,501,292 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,821,758 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	4957
	18286
	ENSG00000136811
	ENSMUSG00000026790
	Q5BJF6
	A3KGV1
NM_001242352; NM_001242353; NM_001242354; NM_002540; NM_153432;
	NM_153433; NM_153435; NM_153436; NM_153437; NM_153439; NM_153440; NM_001351577; NM_001351578; NM_001351579; NM_001351580; NM_001351581; NM_001351582; NM_001351583; NM_001351584; NM_001351585; NM_001351586; NM_001351587; NM_001351588
NM_001113213; NM_001113214; NM_001177659; NM_001177661; NM_013615;
	NM_001355136; NM_001355137; NM_001355138; NM_001369060; NM_001374179; NM_001374180; NM_001374181; NM_001374182
NP_001229281; NP_001229282; NP_001229283; NP_002531; NP_702910;
	NP_702911; NP_702913; NP_702914; NP_702915; NP_702917; NP_702918; NP_001338506; NP_001338507; NP_001338508; NP_001338509; NP_001338510; NP_001338511; NP_001338512; NP_001338513; NP_001338514; NP_001338515; NP_001338516; NP_001338517
NP_001106684; NP_001106685; NP_001171130; NP_001171132; NP_038643;
	NP_001342065; NP_001342066; NP_001342067; NP_001355989; NP_001361108; NP_001361109; NP_001361110; NP_001361111
	Wikidata
View/Edit Human	View/Edit Mouse

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.^[5]^[6]^[7]

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026790 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem. 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620.
^ Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet. 83 (3–4): 221–3. doi:10.1159/000015183. hdl:1807.1/828. PMID 10072582. S2CID 1214379.
^ ^a ^b "Entrez Gene: ODF2 outer dense fiber of sperm tails 2".

Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369. S2CID 28475473.
Hoyer-Fender S, Petersen C, Brohmann H, et al. (1999). "Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail". Mol. Reprod. Dev. 51 (2): 167–75. doi:10.1002/(SICI)1098-2795(199810)51:2<167::AID-MRD6>3.0.CO;2-O. PMID 9740324. S2CID 45285336.
Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa". Mol. Hum. Reprod. 5 (7): 627–35. doi:10.1093/molehr/5.7.627. PMID 10381817.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Soung NK, Kang YH, Kim K, et al. (2007). "Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes". Mol. Cell. Biol. 26 (22): 8316–35. doi:10.1128/MCB.00671-06. PMC 1636773. PMID 16966375.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136811 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026790 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9045620-5] Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem. 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620.

[pmid10072582-6] Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet. 83 (3–4): 221–3. doi:10.1159/000015183. hdl:1807.1/828. PMID 10072582. S2CID 1214379.

[entrez-7] "Entrez Gene: ODF2 outer dense fiber of sperm tails 2".

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