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Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2gene.[5][6]
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID9000130.
Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.
Further reading
Marracci GH, Marquardt WE, Strehlow A, et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID16631599.
Sarkar SN, Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID15502848. S2CID6869429.