Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature
Posted on February 13, 2023 By LabLynx Journal articles
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Chemical compound
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Formula | C20H27N |
Molar mass | 281.443 g·mol−1 |
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Terodiline is a drug used in urology as an antispasmodic.
It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.
However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]
References
- ^ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC 483946. PMID 7662454.
Urologicals, including antispasmodics (G04B) | |
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Acidifiers | |
Urinary antispasmodics (primarily antimuscarinics) | |
Other urologicals |
mAChRsTooltip Muscarinic acetylcholine receptors |
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