Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature
Spectrin alpha chain, erythrocyte is a protein that in humans is encoded by the SPTA1gene.[5]
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.[5]
Gallagher PG, Forget BG (1993). "Spectrin genes in health and disease". Semin. Hematol. 30 (1): 4–20. PMID8094577.
Delaunay J, Dhermy D (1993). "Mutations involving the spectrin heterodimer contact site: clinical expression and alterations in specific function". Semin. Hematol. 30 (1): 21–33. PMID8434258.
Iolascon A, Miraglia del Giudice E, Perrotta S, et al. (1998). "Hereditary spherocytosis: from clinical to molecular defects". Haematologica. 83 (3): 240–57. PMID9573679.
De Matteis MA, Morrow JS (2000). "Spectrin tethers and mesh in the biosynthetic pathway". J. Cell Sci. 113 (13): 2331–43. doi:10.1242/jcs.113.13.2331. PMID10852813.
Hentati A, Hu P, Asgharzadeh S, Siddique T (1993). "Dinucleotide repeat polymorphism at the human erythroid alpha spectrin (SPTA1) locus". Hum. Mol. Genet. 1 (3): 218. doi:10.1093/hmg/1.3.218-a. PMID1339473.
Alloisio N, Wilmotte R, Morlé L, et al. (1992). "Spectrin Jendouba: an alpha II/31 spectrin variant that is associated with elliptocytosis and carries a mutation distant from the dimer self-association site". Blood. 80 (3): 809–15. doi:10.1182/blood.V80.3.809.bloodjournal803809 (inactive 26 April 2024). PMID1638030.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
Kotula L, Laury-Kleintop LD, Showe L, et al. (1991). "The exon-intron organization of the human erythrocyte alpha-spectrin gene". Genomics. 9 (1): 131–40. doi:10.1016/0888-7543(91)90230-C. PMID1672285.