Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature
Contents
Appearance
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Names | |
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Preferred IUPAC name
Diethyl quinolin-3-yl phosphate | |
Other names
3-(Diethoxyphosphinyloxy)-quinoline
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C13H16NO4P | |
Molar mass | 281.248 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Highly toxic |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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1 mg/kg (mice, intravenous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It is the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.[1]
See also
References
- ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.