Protein-coding gene in the species Homo sapiens
MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene .[ 5] [ 6]
Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function [ 7] and addiction. [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000186260 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009569 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (5): 337–45. doi :10.1093/dnares/6.5.337 . PMID 10574462 .
^ "Entrez Gene: MKL2 MKL/myocardin-like 2" .
^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (September 2016). "Emerging roles of the myocardin family of proteins in lipid and glucose metabolism" . J Physiol . 594 (17): 4741–4752. doi :10.1113/JP271913 . PMC 5009794 . PMID 27060572 .
^ Ariza A, Funahashi Y, Kozawa S, Faruk MO, Nagai T, Amano M, Kaibuchi K (2021). "Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK". Journal of Neurochemistry . 157 (6): 1774–1788. doi :10.1111/jnc.15303 . PMID 33449379 . S2CID 231613803 .
Further reading
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" . DNA Res . 9 (3): 99–106. doi :10.1093/dnares/9.3.99 . PMID 12168954 .
Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors" . Proc. Natl. Acad. Sci. U.S.A . 99 (23): 14855–60. Bibcode :2002PNAS...9914855W . doi :10.1073/pnas.222561499 . PMC 137508 . PMID 12397177 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes" . Mol. Cell. Biol . 23 (18): 6597–608. doi :10.1128/MCB.23.18.6597-6608.2003 . PMC 193697 . PMID 12944485 .
Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation" . J. Biol. Chem . 278 (43): 41977–87. doi :10.1074/jbc.M305679200 . PMID 14565952 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling" . J. Cell Biol . 179 (5): 1027–42. doi :10.1083/jcb.200708174 . PMC 2099179 . PMID 18056415 .