Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature
Contents
Dedicator of cytokinesis | |||||||||||
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Identifiers | |||||||||||
Symbol | Ded_cyto | ||||||||||
Pfam | PF06920 | ||||||||||
InterPro | IPR026791 | ||||||||||
SCOP2 | 1wg7 / SCOPe / SUPFAM | ||||||||||
CDD | cd11684 | ||||||||||
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DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.
Subfamilies
DOCK family proteins are categorised into four subfamilies based on their sequence homology:
- DOCK-A subfamily
- DOCK-B subfamily
- DOCK-C subfamily (also known as Zir subfamily)
- DOCK-D subfamily (also known as Zizimin subfamily)
References
- ^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.