Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature

Jakob Berzelius
Born	Jöns Jacob Berzelius (1779-08-10)10 August 1779 Väversunda, Östergötland, Sweden
Died	7 August 1848(1848-08-07) (aged 68) Stockholm, Sweden
Nationality	Swedish
Alma mater	Uppsala University
Known for	Allotropy Atomic weights Bead test Chemical notation Catalysis Discovery of Cerium Discovery of Selenium Discovery of Silicon Discovery of Thorium Isolation of Zirconium Test tube Berzelius beaker
Awards	Pour le Mérite (1842) Copley medal (1836) ForMemRS (1813)
Scientific career
Fields	Chemistry
Institutions	Karolinska Institute
Doctoral advisor	Johann Afzelius
Doctoral students	James Finlay Weir Johnston Heinrich Rose Friedrich Wöhler
Member of the Swedish Academy (Seat No. 5)
In office 20 December 1837 – 7 August 1848
Preceded by	Carl von Rosenstein
Succeeded by	Johan Erik Rydqvist

Baron Jöns Jacob Berzelius (Swedish: [jœns ˈjɑ̌ːkɔb bæˈʂěːlɪɵs]^[1] (20 August 1779 – 7 August 1848) was a Swedish chemist. In general, he is considered the last person to know the whole field of chemistry.^[2] Berzelius is considered, along with Robert Boyle, John Dalton, and Antoine Lavoisier, to be one of the founders of modern chemistry.^[3] Berzelius became a member of the Royal Swedish Academy of Sciences in 1808 and served from 1818 as its principal functionary. He is known in Sweden as the "Father of Swedish Chemistry". During his lifetime he did not customarily use his first given name, and was universally known simply as Jacob Berzelius.^[4]

Although Berzelius began his career as a physician, his enduring contributions were in the fields of electrochemistry, chemical bonding and stoichiometry. In particular, he is noted for his determination of atomic weights and his experiments that led to a more complete understanding of the principles of stoichiometry, which is the branch of chemistry pertaining to the quantitative relationships between elements in chemical compounds and chemical reactions and that these occur in definite proportions. This understanding came to be known as the "Law of Constant Proportions".^[5]

Berzelius was a strict empiricist, expecting that any new theory must be consistent with the sum of contemporary chemical knowledge. He developed improved methods of chemical analysis, which were required to develop the basic data in support of his work on stoichiometry. He investigated isomerism, allotropy, and catalysis, phenomena that owe their names to him.^[6] Berzelius was among the first to articulate the differences between inorganic compounds and organic compounds.^[7][8] Among the many minerals and elements he studied, he is credited with discovering cerium and selenium, and with being the first to isolate silicon and thorium. Following on his interest in mineralogy, Berzelius synthesized and chemically characterized new compounds of these and other elements.

Berzelius demonstrated the use of an electrochemical cell to decompose certain chemical compounds into pairs of electrically opposite constituents. From this research, he articulated a theory that came to be known as electrochemical dualism, contending that chemical compounds are oxide salts, bonded together by electrostatic interactions. This theory, while useful in some contexts, came to be seen as insufficient.^[5] Berzelius's work with atomic weights and his theory of electrochemical dualism led to his development of a modern system of chemical formula notation that showed the composition of any compound both qualitatively and quantitatively. His system abbreviated the Latin names of the elements with one or two letters and applied superscripts to designate the number of atoms of each element present in the compound. Later, chemists changed to use of subscripts rather than superscripts.^[5]

Berzelius was born in the parish of Väversunda in Östergötland in Sweden. His father Samuel Berzelius was a school teacher in the nearby city of Linköping, and his mother Elizabeth Dorothea Sjösteen was a homemaker.^[9] His parents were both from families of church pastors. Berzelius lost both his parents at an early age. His father died in 1779, after which his mother married a pastor named Anders Eckmarck, who gave Berzelius a basic education including knowledge of the natural world. Following the death of his mother in 1787, relatives in Linköping took care of him. There he attended the school today known as Katedralskolan.^[10] As a teenager, he took a position as a tutor at a farm near his home, during which time he became interested in collecting flowers and insects and their classification.^[11]

Berzelius later enrolled as a medical student at Uppsala University, from 1796 to 1801. Anders Gustaf Ekeberg, the discoverer of tantalum, taught him chemistry during this time. He worked as an apprentice in a pharmacy, during which time he also learned practical matters in the laboratory such as glassblowing.^[11] On his own during his studies, he successfully repeated the experimentation conducted by Swedish chemist Carl William Scheele which led to Scheele's discovery of oxygen.^[10] He also worked with a physician in the Medevi mineral springs. During this time, he conducted an analysis of the water from this source. Additionally as part of his studies, in 1800, Berzelius learned about Alessandro Volta's electric pile, the first device that could provide a constant electric current (i.e., the first battery). He constructed a similar battery for himself, consisting of alternating disks of copper and zinc, and this was his initial work in the field of electrochemistry.^[5][11]

As thesis research in his medical studies, he examined the influence of galvanic current on several diseases. This line of experimentation produced no clear-cut evidence for such influence.^[11] Berzelius graduated as a medical doctor in 1802. He worked as a physician near Stockholm until the chemist and mine-owner Wilhelm Hisinger recognized his abilities as an analytical chemist and provided him with a laboratory.^[8]

In 1807, Berzelius was appointed professor in chemistry and pharmacy at the Karolinska Institute.^[5] Between 1808 and 1836, Berzelius worked together with Anna Sundström, who acted as his assistant and was the first female chemist in Sweden.^[12]

In 1808, he was elected a member of the Royal Swedish Academy of Sciences. At this time, the Academy had been stagnating for several years, since the era of romanticism in Sweden had led to less interest in the sciences. In 1818, Berzelius was elected the Academy's secretary and held the post until 1848. During Berzelius' tenure, he is credited with revitalising the Academy and bringing it into a second golden era (the first being the astronomer Pehr Wilhelm Wargentin's period as secretary from 1749 to 1783).^[13] He was elected a Foreign Honorary Member of the American Academy of Arts and Sciences in 1822.^[14] In 1827, he became correspondent of the Royal Institute of the Netherlands, and in 1830 associate member.^[15] In 1837, he was elected a member of the Swedish Academy, on chair number 5.

Berzelius was active in the temperance movement. Along with Bengt Franc-Sparre [sv], August von Hartmansdorff [sv], Anders Retzius, Samuel Owen, George Scott, and others, he was one of the founders of the Svenska nykterhetssällskapet (the Swedish Temperance Society) in 1837 and its first chairman.^[16] Berzelius wrote the foreword to one of Carl af Ekenstam's [sv] works on the topic, of which 50,000 copies were printed.^[17]

Through much of his life, Berzelius suffered various medical ailments. These included recurrent migraine headaches and then later on he suffered from gout. He also had episodes of depression.^[11]

In 1818, Berzelius had a nervous breakdown, said to be due to the stress of his work.^[10] The medical advice he received was to travel and take vacation. However, during this time, Berzelius traveled to France to work in the chemical laboratories of Claude Louis Berthollet.^[11]

In 1835, at the age of 56, he married Elizabeth Poppius, the 24-year-old daughter of a Swedish cabinet minister.^[11]

He died on 7 August 1848 at his home in Stockholm, where he had lived since 1806.^[18] He is buried in the Solna Cemetery.^[10]

Soon after arriving in Stockholm, Berzelius wrote a chemistry textbook for his medical students, Lärbok i Kemien, which was his first significant scientific publication. He had conducted experimentation, in preparation for writing this textbook, on the compositions of inorganic compounds, which was his earliest work on definite proportions.^[5] In 1813–4, he submitted a lengthy essay (published in five separate articles) on the proportions of elements in compounds. The essay commenced with a general description,^[19][20] introduced his new symbolism, and examined all the known elements.^[21][22] The essay ended with a table of the "specific weights" (relative atomic masses) of the elements, where oxygen was set to 100, and a selection of compounds written in his new formalism.^[23][24][25] This work provided evidence in favour of the atomic theory proposed by John Dalton: that inorganic chemical compounds are composed of atoms of different elements combined in whole number amounts. In discovering that atomic weights are not integer multiples of the atomic weight of hydrogen, Berzelius also disproved Prout's hypothesis that elements are built up from atoms of hydrogen.^{[26]: 682–683} Berzelius's last revised version of his atomic weight tables was first published in a German translation of his Textbook of Chemistry in 1826.^[27]

In order to aid his experiments, he developed a system of chemical notation in which the elements composing any particular chemical compound were given simple written labels—such as O for oxygen, or Fe for iron—with their proportions in the chemical compound denoted by numbers. Berzelius thus invented the system of chemical notation still used today, the main difference being that instead of the subscript numbers used today (e.g., H₂O or Fe₂O₃), Berzelius used superscripts (H²O or Fe²O³).^[28]

Berzelius is credited with discovering the chemical elements cerium and selenium and with being the first to isolate silicon, thorium, titanium and zirconium. Berzelius discovered cerium in 1803^[29] and selenium in 1817.^[30] Berzelius also discovered how to isolate silicon in 1824,^[31] and thorium in 1824.^[32][33] Students working in Berzelius's laboratory also discovered lithium, lanthanum, and vanadium.^[34]

Berzelius discovered amorphous silicon by repeating an experiment performed by Gay-Lussac and Thénard in which they reacted silicon tetrafluoride with potassium metal which produced very impure silicon. In a variation of this experiment Berzelius heated potassium fluorosilicate with potassium. It produced potassium silicide which he then stirred with water to produce relatively pure silicon powder. Berzelius recognized this powder as the new element of silicon, which he called silicium,^[35] a name proposed earlier by Davy.^[36]

Berzelius was the first to isolate zirconium in 1824, but pure zirconium was not produced until 1925, by Anton Eduard van Arkel and Jan Hendrik de Boer.^[37]

Berzelius is credited with originating the chemical terms "catalysis",^[38] "polymer," "isomer," "protein" and "allotrope," although his original definitions in some cases differ significantly from modern usage.^[39] As an example, he coined the term "polymer" in 1833 to describe organic compounds which shared identical empirical formulas but which differed in overall molecular weight, the larger of the compounds being described as "polymers" of the smallest.^[40] At this time the concept of chemical structure had not yet been developed so that he considered only the numbers of atoms of each element. In this way, he viewed for example glucose (C₆H₁₂O₆) as a polymer of formaldehyde (CH₂O), even though we now know that glucose is not a polymer of the monomer formaldehyde.^[41]

Berzelius was the first person to make the distinction between organic compounds (those containing carbon), and inorganic compounds. In particular, he advised Gerardus Johannes Mulder in his elemental analyses of organic compounds such as coffee, tea, and various proteins. The term protein itself was coined by Berzelius, in 1838, after Mulder observed that all proteins seemed to have the same empirical formula and came to the erroneous conclusion that they might be composed of a single type of very large molecule. The term is derived from the Greek, meaning "of the first rank", and Berzelius proposed the name because proteins were so fundamental to living organisms.^[42]

In 1808, Berzelius discovered that lactic acid occurs in muscle tissue, not just in milk.

The term biliverdin was coined by Berzelius in 1840, although he preferred "bilifulvin" (yellow/red) over "bilirubin" (red).^[43]

Berzelius stated in 1810 that living things work by some mysterious "vital force",^[44] a hypothesis called vitalism. Vitalism had first been proposed by prior researchers, although Berzelius contended that compounds could be distinguished by whether they required any organisms in their synthesis (organic compounds) or whether they did not (inorganic compounds). However, in 1828, Friedrich Wöhler accidentally obtained urea, an organic compound, by heating ammonium cyanate. This showed that an organic compound such as urea could be prepared synthetically and not exclusively by living organisms. Berzelius corresponded with Wöhler on the urea synthesis findings. However, the notion of vitalism continued to persist, until further work on abiotic synthesis of organic compounds provided substantial evidence against vitalism.^[45][46]

• Berzelius und Liebig: Ihre Briefe von 1831 - 1845 (in German). München: Lehmann. 1893.
• Letters of Jöns Jakob Berzelius and Christian Friedrich Schönbein. London: Williams & Norgate. 1900.
• Selbstbiographische Aufzeichnungen (in German). Leipzig: Johann Ambrosius Barth. 1903.
• Lärbok i kemien (in Swedish). Stockholm, Nordström, 1808-1830.
• Tabell, som utvisar vigten af större delen vid den oorganiska Kemiens studium märkvärdiga enkla och sammansatta kroppars atomer, jemte deras sammansättning, räknad i procent (in Swedish). Stockholm : H.A. Nordström, 1818.

Berzelius was a prolific correspondent with leading scientists of his time, such as Gerardus Johannes Mulder, Claude Louis Berthollet, Humphry Davy, Friedrich Wöhler, Eilhard Mitscherlich and Christian Friedrich Schönbein.

In 1812, Berzelius traveled to London, England, including Greenwich to meet with prominent British scientists of the time. These included Humphry Davy, chemist William Wollaston, physician-scientist Thomas Young, astronomer William Herschel, chemist Smithson Tennant, and inventor James Watt, among others. Berzelius also visited Davy's laboratory. After his visit to Davy's laboratory, Berzelius remarked, "A tidy laboratory is a sign of a lazy chemist."^[39]

Humphry Davy in 1810 proposed that chlorine is an element. Berzelius rejected this claim because of his belief that all acids were based on oxygen. Since chlorine forms a strong acid (muriatic acid, modern HCl), chlorine must contain oxygen and thus cannot be an element. However, in 1812, Bernard Courtois proved that iodine is an element. Then in 1816 Joseph-Louis Gay-Lussac demonstrated that prussic acid (hydrogen cyanide) contains only hydrogen, carbon, and nitrogen, and no oxygen. These findings persuaded Berzelius that not all acids contain oxygen, and that Davy and Gay-Lussac were correct: chlorine and iodine are indeed elements.

In 1818 Berzelius was ennobled by King Carl XIV Johan. In 1835, he received the title of friherre.^[47]

In 1820 he was elected a member of the American Philosophical Society.^[48]

The Royal Society of London gave Berzelius the Copley Medal in 1836 with the citation "For his systematic application of the doctrine of definite proportions to the analysis of mineral bodies, as contained in his Nouveau Systeme de Mineralogie, and in other of his works."^{[citation needed]}

In 1840, Berzelius was named Knight of the Order of Leopold.^[49] In 1842, he received the honor Pour le Mérite for Sciences and Arts.^[50]

The mineral berzelianite, a copper selenide, was discovered in 1850 and named after him by James Dwight Dana.^[51][52]

In 1852, Stockholm, Sweden, built a public park and statue, both to honor Berzelius. Berzeliusskolan, a school situated next to his alma mater, Katedralskolan, is named for him. In 1890, a fairly prominent street in Gothenburg was named Berzeliigatan (Berzelii street) in his honour.

In 1898, the Swedish Academy of Sciences opened the Berzelius Museum in honor of Berzelius. The holdings of the museum included many items from his laboratory. The museum was opened on the occasion of fiftieth anniversary of Berzelius's death. Invitees at the ceremony marking the occasion included scientific dignitaries from eleven European nations and the United States, many of whom gave formal addresses in honor of Berzelius.^[53] The Berzelius Museum was later moved to the observatory that is part of the Swedish Academy of Sciences.^[8]

In 1939 his portrait appeared on a series of postage stamps commemorating the bicentenary of the founding of the Swedish Academy of Sciences.^[54] In addition to Sweden, Grenada likewise honored him.^[11]

The Berzelius secret society at Yale University is named in his honor.

• Berzelius beaker

• Jaime Wisniak (2000). "Jöns Jacob Berzelius A Guide to the Perplexed Chemist". The Chemical Educator. 5 (6): 343–350. doi:10.1007/s00897000430a. S2CID 98774420.
• Paul Walden (1947). "Zum 100. Todestag von Jöns Jakob Berzelius am 7. August 1948". Naturwissenschaften. 34 (11): 321–327. Bibcode:1947NW.....34..321W. doi:10.1007/BF00644137. S2CID 36477981.
• Holmberg, Arne (1933) Bibliografi över J. J. Berzelius. 2 parts in 5 vol. Stockholm: Kungl. Svenska Vetenskapsakademien, 1933–67. 1. del och suppl. 1–2. Tryckta arbeten av och om Berzelius. 2. del och suppl. Manuskript
• Jorpes, J. Erik (1966) Jac. Berzelius – his life and work; translated from the Swedish manuscript by Barbara Steele. Stockholm: Almqvist & Wiksell, 1966. (Reissued by University of California Press, Berkeley, 1970 ISBN 0-520-01628-9)
• Leicester, Henry (1970–1980). "Berzelius, Jöns Jacob". Dictionary of Scientific Biography. Vol. 2. New York: Charles Scribner's Sons. pp. 90–97. ISBN 978-0-684-10114-9.
• Partington, J. R. (1964) History of Chemistry; vol. 4. London: Macmillan; pp. 142–77

• List of works by Berzelius (301 items as of access date 2011-12-29)
• Online works at Project Runeberg (in Latin)
• Works by Jöns Jakob Berzelius at Project Gutenberg
• Works by or about Jöns Jacob Berzelius at the Internet Archive
• Online correspondence between Berzelius and Sir Humphry Davy on Wikisource (in English and French)
• Online works on Gallica (in French and Swedish) (27 items as of access date 2011-12-29)
• Nordisk familjebok (1905), band 3, s. 90–96 (in Swedish)
• Poliakoff, Martyn. Jöns Jacob Berzelius. University of Nottingham: The Periodic Table of Videos.
• Digital edition of "Lehrbuch der Chemie" 1823/1824 by the University and State Library Düsseldorf
• Digital edition of "Das saidschitzer Bitterwasser : chemisch untersucht" 1840 by the University and State Library Düsseldorf
• Digital edition of "Aus Jac. Berzelius' und Gustav Magnus' Briefwechsel in den Jahren 1828–1847" 1900 by the University and State Library Düsseldorf
• "Berzelius, Johan Jakob" . The American Cyclopædia. 1879.

Cultural offices
Preceded by Carl von Rosenstein	Swedish Academy, Seat No. 5 1837–48	Succeeded by Johan Erik Rydqvist