Effects of the storage conditions on the stability of natural and synthetic cannabis in biological matrices for forensic toxicology analysis: An update from the literature
Contents
Asplenia | |
---|---|
Specialty | Medical genetics ![]() |
Asplenia refers to the absence of normal spleen function and is associated with some serious infection risks. Hyposplenism is used to describe reduced ('hypo-') splenic functioning, but not as severely affected as with asplenism.
Functional asplenia occurs when splenic tissue is present but does not work well (e.g. sickle-cell disease, polysplenia) – such patients are managed as if asplenic – while in anatomic asplenia, the spleen itself is absent.
Causes
Congenital
- Congenital asplenia is rare. There are two distinct types of genetic disorders: heterotaxy syndrome[1] and isolated congenital asplenia.[2]
- polysplenia
Acquired
Acquired asplenia occurs for several reasons:
- Following splenectomy due to splenic rupture from trauma or because of tumor
- After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
- After splenectomy with the goal of arresting the progression of cancers (Chronic lymphocytic leukemia,[3] Hodgkin's disease (starting in the 1970s[4]), non-Hodgkin lymphoma[5])
- Due to underlying diseases that destroy the spleen (autosplenectomy), e.g. sickle-cell disease.
- Celiac disease: unknown physiopathology.[6] In a 1970 study,[7] it was the second most common cause of abnormalities of red blood cells linked to hyposplenism, after surgical splenectomy.
Functional asplenia
Functional asplenia can occur when patients with metabolic or haematological disorders have their splenic tissue organisation altered. This can lead to results similar to those seen in patients who have undergone a splenectomy e.g. becoming infected with encapsulated bacteria such as Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. Patients who have some form of asplenia have an increased susceptibility to these encapsulated bacterial infections mainly because they lack IgM memory B cells and their non-adherence to polysaccharide vaccines. Furthermore, there is a deficiency of other splenic cells e.g. splenic macrophages. This combined with the lack of B cells can provide an environment favourable for the development of bacterial infections.[8]
Partial splenectomy and preservation of splenic function
In an effort to preserve some of the spleen's protective roles,[9] attempts are now often made to preserve a small part of the spleen when performing either surgical subtotal (partial) splenectomy,[10] or partial splenic embolization.[11] This may be particularly important in poorer countries where protective measures for patients with asplenia are not available.[12] However, it has been advised that preoperative vaccination is advisable until the remnant splenic tissue can reestablish its function.[13]
Risks
Asplenia is a form of immunodeficiency, increasing the risk of sepsis from polysaccharide encapsulated bacteria,[14] and can result in overwhelming post splenectomy infection (OPSI), often fatal within a few hours. In particular, patients are at risk from Streptococcus pneumoniae, Haemophilus influenzae, and meningococcus.[14] The risk is elevated as much as 350–fold.[15]
The increased risk of infection is due to inability to clear opsonised bacteria from circulating blood. There is also a deficiency of T-cell independent antibodies, such as those reactive to the polysaccharide capsule of Streptococcus pneumoniae.[16]
The risk to asplenic patients has been expressed as equivalent to an adult dying in a road traffic accident (1 to 5 percent of people without spleens would develop a severe infection per decade) (reference UK Splenectomy Trust Advice)—hence sensible precautions are advisable.[17] Increased platelet counts can be seen in individuals without a functioning spleen.
Diagnosis
Diagnosis is confirmed by abdominal ultrasonography and detection of Howell-Jolly bodies in red blood cells.[18]
Management
To minimise the risks associated with splenectomy, antibiotic and vaccination protocols have been established,[19][20][21] but are often poorly adhered to by physicians and patients due to the complications resulting from antibiotic prophylaxis such as development of an overpopulation of Clostridium difficile in the intestinal tract.[22]
Antibiotic prophylaxis
Because of the increased risk of infection, physicians administer oral antibiotics as prophylaxis after a surgical splenectomy, or starting at birth for congenital or functional asplenia.
Those with asplenia are also cautioned to start a full-dose course of antibiotics at the first onset of an upper or lower respiratory tract infection (for example, sore throat or cough), or at the onset of any fever. Even with a course of antibiotics and even with a history of relevant vaccination, persons without a functional spleen are at risk for Overwhelming post-splenectomy infection.[23]
In an emergency room or hospital setting, appropriate evaluation and treatment for an asplenic febrile patient should include a complete blood count with differential, blood culture with Gram stain, arterial blood gas analysis, chest x-ray, and consideration for lumbar puncture with CSF studies. None of these evaluations should delay the initiation of appropriate broad-spectrum intravenous antibiotics. The Surviving Sepsis Campaign guidelines state that antibiotics should be administered to a patient suspected of sepsis within 1 hour of presentation. Delay in starting antibiotics for any reason is associated with a poor outcome.[24]
Vaccinations
It is suggested that splenectomized persons receive the following vaccinations, and ideally prior to planned splenectomy surgery:
- Pneumococcal polysaccharide vaccine (not before 2 years of age). Children may first need one or more boosters of pneumococcal conjugate vaccine if they did not complete the full childhood series.
- Haemophilus influenzae type b vaccine, especially if not received in childhood. For adults who have not been previously vaccinated, two doses given two months apart was advised in the new 2006 UK vaccination guidelines (in the UK may be given as a combined Hib/MenC vaccine).[25]
- Meningococcal conjugate vaccine, especially if not received in adolescence. Previously vaccinated adults require a single booster and non-immunised adults advised, in UK since 2006, to have two doses given two months apart.[25] Children too young for the conjugate vaccine should receive meningococcal polysaccharide vaccine in the interim.[15]
- Influenza vaccine, every winter, to help prevent getting secondary bacterial infection.
Travel measures
In addition to the normal immunizations advised for the countries to be visited, Group A meningococcus should be included if visiting countries of particular risk (e.g. sub-saharan Africa).[26] The non-conjugated Meningitis A and C vaccines usually used for this purpose give only 3 years coverage and provide less-effective long-term cover for Meningitis C than the conjugated form already mentioned.[27]
Those lacking a functional spleen are at higher risk of contracting malaria,[28] and succumbing to its effects. Travel to malarial areas will carry greater risks and is best avoided. Travellers should take the most appropriate anti-malarial prophylaxis medication and be extra vigilant over measures to prevent mosquito bites.[19]
The pneumococcal vaccinations may not cover some of the other strains of pneumococcal bacteria present in other countries. Likewise, their antibiotic resistance may also vary, requiring a different choice of stand-by antibiotic.
Additional measures
- Surgical and dental procedures - Antibiotic prophylaxis may be required before certain surgical or dental procedures.
- Animal bites - adequate antibiotic cover is required after even minor dog or other animal bites. Asplenic patients are particularly susceptible to infection by Capnocytophaga canimorsus and should receive a five-day course of amoxicillin/clavulanate (erythromycin in patients allergic to penicillin).[29]
- Tick bites - Babesiosis is a rare tickborne infection. Patients should check themselves or have themselves inspected for tick bites if they are in an at-risk situation. Presentation with fever, fatigue, and haemolytic anaemia requires diagnostic confirmation by identifying the parasites within red blood cells on blood film and by specific serology. Quinine (with or without clindamycin) is usually an effective treatment.[29]
- Alert warning - People without a working spleen can carry a card, or wear a special bracelet or necklet which says that they do not have a working spleen. This would alert a healthcare professional to take rapid action if they become seriously ill and cannot notify them of their condition.[30]
References
- ^ Online Mendelian Inheritance in Man. OMIM entry 208530: Right atrial isomerism; RAI. Johns Hopkins University. [1]
- ^ Online Mendelian Inheritance in Man. Johns Hopkins University. OMIM entry 271400: Asplenia, isolated congenital; ICAS. Archived 2022-01-22 at the Wayback Machine
- ^ Leukemia & Lymphoma Society (2017). "Chronic Lymphocytic Leukemia" (PDF). p. 15. Archived from the original (PDF) on 18 June 2018. Retrieved 18 June 2018.
- ^ Lowenbraun, Stanley (January 1971). "Splenectomy in Hodgkin's disease for splenomegaly, cytopenias and intolerance to myelosuppressive chemotherapy". The American Journal of Medicine. 50 (1): 49–55. doi:10.1016/0002-9343(71)90204-X. PMID 5539576. Retrieved 18 June 2018.
- ^ Xiros, Nikolao (March 2000). "Splenectomy in patients with malignant non‐Hodgkin's lymphoma". European Journal of Haematology. 64 (3): 145–50. doi:10.1034/j.1600-0609.2000.90079.x. PMID 10997879. S2CID 20986297.
- ^ Halfdanarson, T. R.; Litzow, M. R.; Murray, J. A. (15 January 2007). "Hematologic manifestations of celiac disease". Blood. 109 (2): 412–421. doi:10.1182/blood-2006-07-031104. PMC 1785098. PMID 16973955.
- ^ Ferguson, Anne; Hutton, MargaretM.; Maxwell, J.D.; Murray, D. (January 1970). "Adult Cœlicac Diseases in Hyposplenic Patients". The Lancet. 295 (7639): 163–164. doi:10.1016/S0140-6736(70)90405-8. PMID 4189238.
- ^ Tarantino, Giovanni (2013). "Liver-spleen axis: Intersection between immunity, infections and metabolism". World Journal of Gastroenterology. 19 (23): 3534–42. doi:10.3748/wjg.v19.i23.3534. ISSN 1007-9327. PMC 3691032. PMID 23801854.
- ^ Grosfeld JL, Ranochak JE (1976). "Are hemisplenectomy and/or primary splenic repair feasible?". J. Pediatr. Surg. 11 (3): 419–24. doi:10.1016/S0022-3468(76)80198-4. PMID 957066.
- ^ Bader-Meunier B, Gauthier F, Archambaud F, et al. (2001). "Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis". Blood. 97 (2): 399–403. doi:10.1182/blood.V97.2.399. PMID 11154215. S2CID 22741973.
- ^ Pratl B, Benesch M, Lackner H, et al. (2007). "Partial splenic embolization in children with hereditary spherocytosis". European Journal of Haematology. 80 (1): 76–80. doi:10.1111/j.1600-0609.2007.00979.x. PMID 18028435. S2CID 41343243.
- ^ Sheikha AK, Salih ZT, Kasnazan KH, et al. (2007). "Prevention of overwhelming postsplenectomy infection in thalassemia patients by partial rather than total splenectomy". Canadian Journal of Surgery. 50 (5): 382–6. PMC 2386178. PMID 18031639.
- ^ Kimber C, Spitz L, Drake D, et al. (1998). "Elective partial splenectomy in childhood". Journal of Pediatric Surgery. 33 (6): 826–9. doi:10.1016/S0022-3468(98)90651-0. PMID 9660206.
- ^ a b Brigden, M. L. (2001). "Detection, education and management of the asplenic or hyposplenic patient". American Family Physician. 63 (3): 499–506, 508. PMID 11272299.
- ^ a b AAP Red Book 2006.
- ^ Kasper, D. et al (2015) Harrison's principles of internal medicine. New York, NY: McGraw-Hill Education
- ^ "Splenectomy and Infection" (PDF). Splenectomy Trust. March 2002. Archived from the original (PDF) on 2007-09-28. Retrieved 2006-12-12. - reprint from Kent and Medway NHS and Social Care Partnership Trust
- ^ "Asplenia/Hyposplenia". Unbound Medicine, Inc. Archived from the original on 9 July 2021. Retrieved 9 July 2021.
- ^ a b Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force (1996). "Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force". BMJ. 312 (7028): 430–4. doi:10.1136/bmj.312.7028.430. PMC 2350106. PMID 8601117.
- ^ Davies JM; et al. (2001-06-02). "The prevention and treatment of infection in patients with an absent or dysfunctional spleen - British Committee for Standards in Haematology Guideline up-date". BMJ. 312 (7028): 430–4. doi:10.1136/bmj.312.7028.430. PMC 2350106. PMID 8601117. - published as a response by original authors
- ^ Davies JM, Barnes R, Milligan D, British Committee for Standards in Haematology - Working Party of the Haematology-Oncology Task Force (2002). "Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen" (PDF). Clinical Medicine. 2 (5): 440–3. doi:10.7861/clinmedicine.2-5-440. PMC 4953085. PMID 12448592. Archived from the original (PDF) on 2009-11-05. Retrieved 2010-02-01.
- ^ Waghorn DJ (2001). "Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed". Journal of Clinical Pathology. 54 (3): 214–8. doi:10.1136/jcp.54.3.214. PMC 1731383. PMID 11253134.
- ^ Wick, Jeannette (September 1, 2006). "Asplenia Poses Management Challenges". Pharmacy Times. Archived from the original on April 12, 2013. Retrieved 18 June 2018.
- ^ Huebner, Mitchell; Kristin, Kristin (July 2015). "Asplenia and fever". Baylor University Medical Center Proceedings. 28 (3): 340–1. doi:10.1080/08998280.2015.11929267. PMC 4462215. PMID 26130882.
- ^ a b Joint Committee on Vaccination and Immunisation (21 December 2006). "Chapter 7 : Immunisation of individuals with underlying medical conditions". In Editors Salisbury D, Ramsay M, Noakes K (eds.). Immunisation Against Infectious Disease 2006 (PDF). Edinburgh: Stationery Office. ISBN 978-0-11-322528-6. Archived from the original on 2 December 2008. Retrieved 22 July 2007. - see pages 50-1 and table 7.1
- ^ "Meningococcal - Children and adults with asplenia or splenic dysfunction" (PDF). Immunization against infectious disease - 'The Green Book' (PDF). 24 August 2009 [2006]. p. 244. Archived from the original on 26 July 2020. Retrieved 7 November 2009.
- ^ Chief Medical Officer (2001). "Meningococcal immunisation for asplenic patients" (PDF). Professional Letter: Chief Medical Officer - Current Vaccine and Immunization Issues. 1. Department of Health: 4. Retrieved 2009-11-07.[permanent dead link]
- ^ Boone KE, Watters DA (November 1995). "The incidence of malaria after splenectomy in Papua New Guinea". BMJ. 311 (7015): 1273. doi:10.1136/bmj.311.7015.1273. PMC 2551185. PMID 7496237.
- ^ a b "Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen" (PDF). Wilton, Cork, Ireland: Health Service Executive, Southern Area. September 2002. Archived from the original on 2012-03-04. Retrieved 2009-10-09.
- ^ HSC Public Health Agency. "Splenectomy wallet card". HSC Public Health Agency. Belfast. Archived from the original on 2 August 2019. Retrieved 1 August 2019.