Protein-coding gene in the species Homo sapiens
AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene .[ 5] [ 6] [ 7]
Function
AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM][ 7]
Interactions
AP3D1 has been shown to interact with SYBL1 .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000065000 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020198 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3" . The Journal of Cell Biology . 137 (4): 835–45. doi :10.1083/jcb.137.4.835 . PMC 2139840 PMID 9151686 . ^ Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS (Aug 1997). "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet" . The EMBO Journal . 16 (15): 4508–18. doi :10.1093/emboj/16.15.4508 . PMC 1170077 PMID 9303295 . ^ a b "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit" .^ Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs" . Proceedings of the National Academy of Sciences of the United States of America . 100 (15): 9011–6. Bibcode :2003PNAS..100.9011M . doi :10.1073/pnas.1431910100 PMC 166429 PMID 12853575 .
External links
Further reading
Höning S, Sandoval IV, von Figura K (Aug 1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3" . The EMBO Journal . 17 (5): 1304–14. doi :10.1093/emboj/17.5.1304 . PMC 1170479 PMID 9482728 . Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M (Jul 1998). "Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles" . Neuron . 21 (1): 111–22. doi :10.1016/S0896-6273(00)80519-X PMID 9697856 . S2CID 17237941 . Rehling P, Darsow T, Katzmann DJ, Emr SD (2000). "Formation of AP-3 transport intermediates requires Vps41 function". Nature Cell Biology . 1 (6): 346–53. doi :10.1038/14037 . PMID 10559961 . S2CID 24932376 . Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC (May 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif" . Virology . 271 (1): 9–17. doi :10.1006/viro.2000.0277 PMID 10814565 . Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G (May 2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic" . The EMBO Journal . 20 (9): 2191–201. doi :10.1093/emboj/20.9.2191 . PMC 125242 PMID 11331585 . Austin C, Boehm M, Tooze SA (Apr 2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry . 41 (14): 4669–77. doi :10.1021/bi016064j . PMID 11926829 . Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J (Mar 2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes" . The Journal of Biological Chemistry . 278 (10): 8725–32. doi :10.1074/jbc.M210115200 PMID 12486136 . Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (Sep 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1" . Developmental Cell . 5 (3): 513–21. doi :10.1016/S1534-5807(03)00234-X PMID 12967569 . Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (Feb 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation" . Molecular Biology of the Cell . 15 (2): 575–87. doi :10.1091/mbc.E03-06-0401 . PMC 329249 PMID 14657250 . Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (Oct 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes" . Developmental Cell . 7 (4): 619–25. doi :10.1016/j.devcel.2004.08.009 PMID 15469849 . Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC (Feb 2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes" . Journal of Virology . 79 (4): 2066–78. doi :10.1128/JVI.79.4.2066-2078.2005 . PMC 546596 PMID 15681409 . Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P (Mar 2005). "AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly" . Cell . 120 (5): 663–74. doi :10.1016/j.cell.2004.12.023 PMID 15766529 . S2CID 14528434 . Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G (2006). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes" . Molecular Biology of the Cell . 16 (11): 5356–72. doi :10.1091/mbc.E05-07-0626 . PMC 1266432 PMID 16162817 .
