Protein-coding gene in the species Homo sapiens
AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene .[ 5] [ 6]
Function
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.[ 7]
Interactions
AP1M1 has been shown to interact with VAMP4 [ 8] AP1G1 .[ 9] [ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000072958 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003033 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics . 50 (2): 275–80. doi :10.1006/geno.1998.5289 . PMID 9653655 . ^ Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Jan 2008). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin" . Traffic . 9 (1): 121–32. doi :10.1111/j.1600-0854.2007.00672.x PMID 17988225 . ^ "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit" .^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1" . EMBO Reports . 4 (12): 1182–9. doi :10.1038/sj.embor.7400018 . PMC 1326413 PMID 14608369 . ^ Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells" . Cell . 99 (2): 189–98. doi :10.1016/S0092-8674(00)81650-5 PMID 10535737 . S2CID 15288582 . ^
Further reading
Geyer M, Fackler OT, Peterlin BM (Jul 2001). "Structure--function relationships in HIV-1 Nef" . EMBO Reports . 2 (7): 580–5. doi :10.1093/embo-reports/kve141 . PMC 1083955 PMID 11463741 . Bénichou S, Benmerah A (Jan 2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]" . Médecine/Sciences . 19 (1): 100–6. doi :10.1051/medsci/2003191100 PMID 12836198 . Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (Sep 1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science . 269 (5232): 1872–5. Bibcode :1995Sci...269.1872O . doi :10.1126/science.7569928 . PMID 7569928 . Seaman MN, Sowerby PJ, Robinson MS (Oct 1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network" . The Journal of Biological Chemistry . 271 (41): 25446–51. doi :10.1074/jbc.271.41.25446 PMID 8810314 . Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D (Jan 1997). "The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane" . Immunity . 6 (1): 67–77. doi :10.1016/S1074-7613(00)80243-5 PMID 9052838 . Foti M, Mangasarian A, Piguet V, Lew DP, Krause KH, Trono D, Carpentier JL (Oct 1997). "Nef-mediated clathrin-coated pit formation" . The Journal of Cell Biology . 139 (1): 37–47. doi :10.1083/jcb.139.1.37 . PMC 2139808 PMID 9314527 . Ohno H, Aguilar RC, Fournier MC, Hennecke S, Cosson P, Bonifacino JS (Nov 1997). "Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family" . Virology . 238 (2): 305–15. doi :10.1006/viro.1997.8839 PMID 9400603 . Piguet V, Chen YL, Mangasarian A, Foti M, Carpentier JL, Trono D (May 1998). "Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes" . The EMBO Journal . 17 (9): 2472–81. doi :10.1093/emboj/17.9.2472 . PMC 1170589 PMID 9564030 . Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O (Apr 1998). "Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules" . Immunity . 8 (4): 483–95. doi :10.1016/S1074-7613(00)80553-1 PMID 9586638 . Craig HM, Pandori MW, Guatelli JC (Sep 1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity" . Proceedings of the National Academy of Sciences of the United States of America . 95 (19): 11229–34. Bibcode :1998PNAS...9511229C . doi :10.1073/pnas.95.19.11229 PMC 21624 PMID 9736718 . Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC (Nov 1998). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor" . Current Biology . 8 (22): 1235–8. Bibcode :1998CBio....8.1235B . doi :10.1016/S0960-9822(07)00517-9 PMID 9811606 . S2CID 16541580 . Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T (Nov 1998). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4" . Current Biology . 8 (22): 1239–42. Bibcode :1998CBio....8.1239G . doi :10.1016/S0960-9822(07)00518-0 PMID 9811611 . S2CID 14272751 . Owen DJ, Evans PR (Nov 1998). "A structural explanation for the recognition of tyrosine-based endocytotic signals" . Science . 282 (5392): 1327–32. Bibcode :1998Sci...282.1327O . doi :10.1126/science.282.5392.1327 . PMC 5600252 PMID 9812899 . Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins" . Journal of Virology . 73 (2): 1350–61. doi :10.1128/JVI.73.2.1350-1361.1999 . PMC 103959 PMID 9882340 . Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells" . Cell . 99 (2): 189–98. doi :10.1016/S0092-8674(00)81650-5 PMID 10535737 . S2CID 15288582 . Orzech E, Cohen S, Weiss A, Aroeti B (May 2000). "Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells" . The Journal of Biological Chemistry . 275 (20): 15207–19. doi :10.1074/jbc.275.20.15207 PMID 10809756 . Umeda A, Meyerholz A, Ungewickell E (May 2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation". European Journal of Cell Biology . 79 (5): 336–42. doi :10.1078/S0171-9335(04)70037-0 . PMID 10887964 . Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N (Nov 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex" . Cell . 103 (4): 569–81. doi :10.1016/S0092-8674(00)00161-6 PMID 11106728 . S2CID 18245989 .
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