Cybersecurity and privacy risk assessment of point-of-care systems in healthcare: A use case approach

IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	66,254,622 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	120,038,035 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	11213
	73914
	ENSG00000090376
	ENSMUSG00000020227
	Q9Y616
	Q8K4B2
	NM_007199; NM_001142523
	NM_028679; NM_001359184
	NP_001135995; NP_009130
	NP_082955; NP_001346113
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.^[5]^[6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
^ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
^ Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60): 60. doi:10.1038/s41420-018-0056-3. PMC 5955943. PMID 29796309.

Rosati O, Martin MU (May 2002). "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
Bin LH, Xu LG, Shu HB (July 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E (November 2003). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437.
del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E (March 2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". Journal of Immunology. 174 (5): 3032–40. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
Su J, Xie Q, Wilson I, Li L (July 2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling". Cellular Signalling. 19 (7): 1596–601. doi:10.1016/j.cellsig.2007.02.009. PMC 1978187. PMID 17379480.
Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics. 80 (6): 1103–14. doi:10.1086/518259. PMC 1867098. PMID 17503328.
Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID 17558906. S2CID 22703718.
van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T (November 2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". Journal of Immunology. 179 (10): 7110–20. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.

External links

Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090376 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020227 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10383454-5] Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.

[entrez-6] "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".

[Soni_2018-7] Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60): 60. doi:10.1038/s41420-018-0056-3. PMC 5955943. PMID 29796309.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Cybersecurity and privacy risk assessment of point-of-care systems in healthcare: A use case approach

References

Further reading

External links