Potency and safety analysis of hemp-derived delta-9 products: The hemp vs. cannabis demarcation problem

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  • 1-pentyl-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass349.478 g·mol−1
3D model (JSmol)
  • CCCCCN1N=C(C(=O)NC(C)(C)C2=CC=CC=C2)C2=CC=CC=C12
  • InChI=1S/C22H27N3O/c1-4-5-11-16-25-19-15-10-9-14-18(19)20(24-25)21(26)23-22(2,3)17-12-7-6-8-13-17/h6-10,12-15H,4-5,11,16H2,1-3H3,(H,23,26)

CUMYL-PINACA (also known as SGT-24) is an indazole-3-carboxamide based synthetic cannabinoid. CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with approximately 3x selectivity for CB1, having an EC50 of 0.15nM for human CB1 receptors and 0.41nM for human CB2 receptors.[1] In its pure form, it is described as a sticky oil which can cause poisoning through transdermal exposure.[2]

Legal status

Sweden's public health agency suggested classifying CUMYL-PINACA as a hazardous substance, on November 10, 2014.[3]

See also


  1. ^ Bowden; et al. (11 April 2013). "Patent WO 2014167530 - Cannabinoid compounds". New Zealand Patent application 623626. Retrieved 11 July 2015.
  2. ^ Dobaja M, Grenc D, Kozelj G, Brvar M (March 2017). "Occupational transdermal poisoning with synthetic cannabinoid cumyl-PINACA". Clinical Toxicology. 55 (3): 193–195. doi:10.1080/15563650.2016.1278224. PMID 28084855. S2CID 21304629.
  3. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara". Retrieved 11 July 2015.