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In this brief article published in Cytometry Part A, researchers at the Austrian Centre for Industrial Biotechnology present their open-source multiplex fluorescence in situ hybridization (M‐FISH) software for chromosome painting. The tool—ChromaWizard—acts as a free and open-source option for hybridization analysis, integrating "image processing, multicolor integration, chromosome separation, and visualization with false color assignments." The software can handle images in TIFF, PNG, and JPEG formats and provides robust visualization tools. The authors conclude that ChromaWizard "allows direct inspection of the original hybridization signals and enables either manual or automatic assignment of colors, making it a functional and versatile tool that can also be used for other multicolor applications."
In this brief article published in BMC Bioinformatics, Wang and LaFramboise address the topic of cytogenetic data and their genomic coordinates, which the authors describe as "precisely [specifying] a chromosomal location according to its distance from the end of the chromosome." The authors note that despite changes in techniques over the years, the use of karyotype and cytogenetic nomenclature was the primary way of characterizing aberrations in chromosomes, and those methods are still being used today. Additionally, archival data used karyotypes and cytogenetic nomenclature. Given the lack of a maintained, robust tool for converting that nomenclature to genomic coordinates, the authors address their creation, CytoConverter, and explain how it accomplishes such conversions. They conclude that the tool should have "considerable value to the community for analyzing archival patient samples, as well as samples for which higher-resolution copy number data is unavailable."
This document is based on a presentation delivered by chemist and automation consultant Joe Liscouski at the 2nd Annual Lab Asset & Facility Management in Pharma 2019 conference held in San Diego, CA, on October 22nd, 2019. It is not a verbatim transcript, but an expansion of the material presented. The presentation addressed the importance of effective technology management and planning within scientific work. With improved technology management and planning, "[t]hat work should yield better organized systems, reduced costs, better workflows, and improved ROI. How do you go about it? That is what we’ll start to address in this material."
