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25I-NBOH (NBOH-2CI, Cimbi-27) je fenetilaminski halucinogen. On deluje kao potentan agonist5HT2Areceptora,[1][2] sa Ki od 0,061 nM na ljudskom 5HT2A receptoru, te je dvanaest puta potentniji od liganda 2C-I. In vitro testovi su pokazali da ovo jedinjenje deluje kao agonist, ali rezultati životinjskih studija nisu objavljeni. Dok su N-benzilni derivati 2C-I liganda znatno povećavali potentnost, N-benzil derivati 2,5-dimetoksi-4-jodoamfetamina su neaktivni.[3]
Reference
^Ettrup, A.; et al. (2010). „Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers”. European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681—693. PMID21174090. doi:10.1007/s00259-010-1686-8. ISBN 0-02-590101686-8.
^Silva ME, Heim R, Strasser A, Elz S, Dove S (2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design. 25 (1): 51—66. PMID21088982. doi:10.1007/s10822-010-9400-2.
^Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE (2006). „Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists”. Molecular Pharmacology. 70 (6): 1956—64. PMID17000863. doi:10.1124/mol.106.028720.
