Knowledge Base Wiki

Search for LIMS content across all our Wiki Knowledge Bases.

Type a search term to find related articles by LIMS subject matter experts gathered from the most trusted and dynamic collaboration tools in the laboratory informatics industry.

Peptidilprolilna izomeraza
Identifikatori
EC broj 5.2.1.8
CAS broj 95076-93-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Peptidilprolilna izomeraza (EC 5.2.1.8, PPIaza, ciklofilin, peptid vezana izomeraza, peptidilna-prolil cis-trans izomeraza) je enzim sa sistematskim imenom peptidilprolin cis-trans-izomeraza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidilnaprolin (omega = 180) peptidilnaprolin (omega = 0)

Prvi pronađeni tip ovog enzima je proteinski ciklofilin, koji vezuje imunosupresant ciklosporin A. Postoje druge distinktne familije. Među njima su FK-506 vezujući proteini (FKBP).

Reference

  1. ↑ Fischer, G. and Bang, H. (1985). „The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase”. Biochim. Biophys. Acta 828: 39-42. PMID 3882150. 
  2. ↑ Fischer, G., Bang, H. and Mech, C. (1984). „[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides]”. Biomed. Biochim. Acta 43: 1101-1111. PMID 6395866. 
  3. ↑ Fischer, G., Wittmann-Liebold, B., Lang, K., Kiefhaber, T. and Schmid, F.X. (1989). „Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins”. Nature 337: 476-478. PMID 2492638. 
  4. ↑ Takahashi, N., Hayano, T. and Suzuki, M. (1989). „Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin”. Nature 337: 473-475. PMID 2644542. 
  5. ↑ Hennig, L., Christner, C., Kipping, M., Schelbert, B., Rucknagel, K.P., Grabley, S., Kullertz, G. and Fischer, G. (1998). „Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone”. Biochemistry 37: 5953-5960. PMID 9558330. 
  6. ↑ Fischer, G. (1994). „Peptidyl-prolyl cis/trans isomerases and their effectors”. Angew. Chem. Int. Ed. Engl. 33: 1415-1436. 
  7. ↑ Harrison, R.K. and Stein, R.L. (1990). „Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes”. Biochemistry 29: 3813-3816. PMID 1693856. 
  8. ↑ Eisenmesser, E.Z., Bosco, D.A., Akke, M. and Kern, D. (2002). „Enzyme dynamics during catalysis”. Science 295: 1520-1523. PMID 11859194. 

Literatura

Spoljašnje veze

source: https://sh.wikipedia.org/wiki/Ciklofilin