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Limfotoksin beta receptor (TNFR superfamilija, član 3)
	; Kristalografska struktura peptida sa 24 ostatka iz limfotoksin-B receptora vezanog za TRAF3.
Dostupne strukture
	1RF3
Identifikatori
Simboli	LTBR; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
Vanjski ID	OMIM: 600979 MGI: 104875 HomoloGene: 1753 GeneCards: LTBR Gene
Ontologija gena
Molekularna funkcija	• aktivnost transmembranskog receptora; • proteinsko vezivanje;
Celularna komponenta	• membrana; • integralno sa membranom;
Biološki proces	• apoptoza; • imunski respons; • prenos signala; • positivna regulacija I-kapaB kinaza/NF-kapaB kaskade;
Pregled RNK izražavanja
	podaci
Ortolozi

Limfotoksin beta receptor je receptor za limfotoksin koji je kod ljudi kodiran LTBR genom.^[2]^[3]^[4]

Funkcija

Protein kodiran ovim genom je član TNF familije receptora. On je izražen na površini većine ćelijskih tipova, uključujući ćelije epitelnog i mijeloidnog porekla, ali ne na T i B limfocitima. Ovaj protein specifično vezuje limfotoksin membransku formu (kompleks limfotoksina-alfa i limftoksina-beta se formira). Limftoksin-beta i njegov ligand učestvuju u razvoju i organizaciji limfoidnog tkiva. Aktivacija ovog proteina može da podstakne apoptozu.^[2]

Ne samp da LTBR pomaže u podsticanju apoptoze, on može da dovede do oslobađanja citokina interleukin 8. Prekomerno LTBR izražavanje u HEK293 ćelima povećava IL-8 promotorsku aktivnost, i dovodi do IL-8 oslobađanja. LTBR je takođe esencijalan za razvoj i organizaciju sekundarnih limfoidnih organa i oslobađanje drugih hemokina.^[5]

Struktura

Ramačandranov dijagram pokazuje da je 64.6% ostataka u poželjnom regionu.^[6] Ova structura je ustanovljena putem difrakcije X-zraka. Njena rezolucija je 3.50 Å. Alfa i beta uglovi su 90 stepeni, dok je gama ugao 120 stepeni.

Interakcije

Za limfotoksin beta receptor je bilo pokazano da interaguje sa Dijablo homologom^[7] i TRAF3.^[8]^[9]^[10]

Reference

↑ ’PDB 1RF3; Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). „Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling”. J. Biol. Chem. 278 (50): 50523–9. DOI:10.1074/jbc.M309381200. PMID 14517219.
↑ ^2,0 ^2,1 „Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)”.
↑ Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid”. Genomics 16 (1): 214–8. DOI:10.1006/geno.1993.1161. PMID 8486360.
↑ Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). „A lymphotoxin-beta-specific receptor”. Science (journal) 264 (5159): 707–10. DOI:10.1126/science.8171323. PMID 8171323.
↑ Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”. Exp. Cell Res. 278 (2): 166–74. DOI:10.1006/excr.2002.5573. PMID 12169272.
↑ „MolProbity Ramachandran analysis”. Arhivirano iz originala na datum 2012-10-12.
↑ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (April 2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. (United States) 278 (16): 14363–9. DOI:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.
↑ VanArsdale, T L; VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F (March 1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (6): 2460–5. DOI:10.1073/pnas.94.6.2460. ISSN 0027-8424. PMC 20110. PMID 9122217.
↑ Wu, M Y; Wang P Y, Han S H, Hsieh S L (April 1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”. J. Biol. Chem. (UNITED STATES) 274 (17): 11868–73. DOI:10.1074/jbc.274.17.11868. ISSN 0021-9258. PMID 10207006.
↑ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May 1997). „Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1”. J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. DOI:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.

Literatura

Elewaut D, Ware CF (2007). „The unconventional role of LT alpha beta in T cell differentiation.”. Trends Immunol. 28 (4): 169–75. DOI:10.1016/j.it.2007.02.005. PMID 17336158.
Browning JL, Ngam-ek A, Lawton P, et al. (1993). „Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.”. Cell 72 (6): 847–56. DOI:10.1016/0092-8674(93)90574-A. PMID 7916655.
Crowe PD, VanArsdale TL, Walter BN, et al. (1994). „A lymphotoxin-beta-specific receptor.”. Science 264 (5159): 707–10. DOI:10.1126/science.8171323. PMID 8171323.
Baens M, Chaffanet M, Cassiman JJ, et al. (1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.”. Genomics 16 (1): 214–8. DOI:10.1006/geno.1993.1161. PMID 8486360.
Baens M, Aerssens J, van Zand K, et al. (1996). „Isolation and regional assignment of human chromosome 12p cDNAs.”. Genomics 29 (1): 44–52. DOI:10.1006/geno.1995.1213. PMID 8530100.
Wang X, Bornslaeger EA, Haub O, et al. (1996). „A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.”. Dev. Biol. 177 (1): 274–90. DOI:10.1006/dbio.1996.0162. PMID 8660894.
Nakano H, Oshima H, Chung W, et al. (1996). „TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.”. J. Biol. Chem. 271 (25): 14661–4. DOI:10.1074/jbc.271.25.14661. PMID 8663299.
Matsumoto M, Hsieh TY, Zhu N, et al. (1997). „Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.”. J. Virol. 71 (2): 1301–9. PMC 191185. PMID 8995654.
VanArsdale TL, VanArsdale SL, Force WR, et al. (1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.”. Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. DOI:10.1073/pnas.94.6.2460. PMC 20110. PMID 9122217.
Wu MY, Hsu TL, Lin WW, et al. (1997). „Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells.”. J. Biol. Chem. 272 (27): 17154–9. DOI:10.1074/jbc.272.27.17154. PMID 9202035.
Chen CM, You LR, Hwang LH, Lee YH (1997). „Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor.”. J. Virol. 71 (12): 9417–26. PMC 230246. PMID 9371602.
Mizushima S, Fujita M, Ishida T, et al. (1998). „Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).”. Gene 207 (2): 135–40. DOI:10.1016/S0378-1119(97)00616-1. PMID 9511754.
Krajewska M, Krajewski S, Zapata JM, et al. (1998). „TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.”. Am. J. Pathol. 152 (6): 1549–61. PMC 1858434. PMID 9626059.
Boussaud V, Soler P, Moreau J, et al. (1999). „Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung.”. Eur. Respir. J. 12 (4): 926–31. DOI:10.1183/09031936.98.12040926. PMID 9817170.
Murphy M, Walter BN, Pike-Nobile L, et al. (1999). „Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.”. Cell Death Differ. 5 (6): 497–505. DOI:10.1038/sj.cdd.4400374. PMID 10200501.
Wu MY, Wang PY, Han SH, Hsieh SL (1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.”. J. Biol. Chem. 274 (17): 11868–73. DOI:10.1074/jbc.274.17.11868. PMID 10207006.
Yu KY, Kwon B, Ni J, et al. (1999). „A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.”. J. Biol. Chem. 274 (20): 13733–6. DOI:10.1074/jbc.274.20.13733. PMID 10318773.
Rooney IA, Butrovich KD, Glass AA, et al. (2000). „The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.”. J. Biol. Chem. 275 (19): 14307–15. DOI:10.1074/jbc.275.19.14307. PMID 10799510.
Langeggen H, Berge KE, Johnson E, Hetland G (2003). „Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro.”. Inflammation 26 (3): 103–10. DOI:10.1023/A:1015585530204. PMID 12083416.
Chang YH, Hsieh SL, Chen MC, Lin WW (2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.”. Exp. Cell Res. 278 (2): 166–74. DOI:10.1006/excr.2002.5573. PMID 12169272.

Spoljašnje veze

MeSH Lymphotoxin+beta+Receptor

[pmid14517219-1] ’PDB 1RF3; Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). „Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling”. J. Biol. Chem. 278 (50): 50523–9. DOI:10.1074/jbc.M309381200. PMID 14517219.

[entrez-2] 2,0 ^2,1 „Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)”.

[pmid8486360-3] Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid”. Genomics 16 (1): 214–8. DOI:10.1006/geno.1993.1161. PMID 8486360.

[pmid8171323-4] Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). „A lymphotoxin-beta-specific receptor”. Science (journal) 264 (5159): 707–10. DOI:10.1126/science.8171323. PMID 8171323.

[pmid12169272-5] Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”. Exp. Cell Res. 278 (2): 166–74. DOI:10.1006/excr.2002.5573. PMID 12169272.

[6] „MolProbity Ramachandran analysis”. Arhivirano iz originala na datum 2012-10-12.

[pmid12571250-7] Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (April 2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. (United States) 278 (16): 14363–9. DOI:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.

[pmid9122217-8] VanArsdale, T L; VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F (March 1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (6): 2460–5. DOI:10.1073/pnas.94.6.2460. ISSN 0027-8424. PMC 20110. PMID 9122217.

[pmid10207006-9] Wu, M Y; Wang P Y, Han S H, Hsieh S L (April 1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”. J. Biol. Chem. (UNITED STATES) 274 (17): 11868–73. DOI:10.1074/jbc.274.17.11868. ISSN 0021-9258. PMID 10207006.

[pmid9162022-10] Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May 1997). „Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1”. J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. DOI:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.

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Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350