Protein-coding gene in the species Homo sapiens
Acid-sensing ion channel 3 (ASIC3 ) also known as amiloride-sensitive cation channel 3 (ACCN3 ) or testis sodium channel 1 (TNaC1 ) is a protein that in humans is encoded by the ASIC3 gene . The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals.[ 5] [ 6] [ 7]
These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.[ 8]
Structure and function
This gene encodes a member of the ASIC/ENaC superfamily of proteins.[ 9] amiloride -sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.[ 5]
Interactions
ASIC3 has been shown to interact with LIN7B ,[ 10] GOPC [ 10] MAGI1 .[ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000213199 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038276 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Hanukoglu I (2017). "ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters" . FEBS Journal . 284 (4): 525–545. doi :10.1111/febs.13840 . PMID 27580245 . S2CID 24402104 . ^ Ishibashi K, Marumo F (June 1998). "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis". Biochem. Biophys. Res. Commun . 245 (2): 589–93. doi :10.1006/bbrc.1998.8483 . PMID 9571199 . ^ de Weille JR, Bassilana F, Lazdunski M, Waldmann R (October 1998). "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel" . FEBS Lett . 433 (3): 257–60. Bibcode :1998FEBSL.433..257D . doi :10.1016/S0014-5793(98)00916-8 PMID 9744806 . S2CID 24431941 . ^ Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+" . The Journal of Biological Chemistry . 275 (37): 28519–25. doi :10.1074/jbc.M004114200 hdl :11380/304669 PMID 10842183 . ^ Hanukoglu I, Hanukoglu A (Jan 2016). "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases" . Gene . 579 (2): 95–132. doi :10.1016/j.gene.2015.12.061 . PMC 4756657 PMID 26772908 . ^ a b c Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8. doi :10.1074/jbc.M405874200 PMID 15317815 .
External links
Further reading
Babinski K, Lê KT, Séguéla P (1999). "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties" . J. Neurochem . 72 (1): 51–7. doi :10.1046/j.1471-4159.1999.0720051.x PMID 9886053 . S2CID 10506798 . Catarsi S, Babinski K, Séguéla P (2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology . 41 (5): 592–600. doi :10.1016/S0028-3908(01)00107-1 . PMID 11587714 . S2CID 568441 . Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM (2002). "Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system" . Proc. Natl. Acad. Sci. U.S.A . 99 (4): 2326–31. Bibcode :2002PNAS...99.2326A . doi :10.1073/pnas.042688199 PMC 122364 PMID 11842212 . Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons" . J. Biol. Chem . 277 (19): 16655–61. doi :10.1074/jbc.M201087200 PMID 11872753 . Chen CC, Zimmer A, Sun WH, Hall J, Brownstein MJ, Zimmer A (2002). "A role for ASIC3 in the modulation of high-intensity pain stimuli" . Proc. Natl. Acad. Sci. U.S.A . 99 (13): 8992–7. Bibcode :2002PNAS...99.8992C . doi :10.1073/pnas.122245999 PMC 124411 PMID 12060708 . Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 2029–34. Bibcode :2003PNAS..100.2029L . doi :10.1073/pnas.252782799 PMC 149953 PMID 12578970 . Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8. doi :10.1074/jbc.M405874200 PMID 15317815 . Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ (2004). "Stomatin modulates gating of acid-sensing ion channels" . J. Biol. Chem . 279 (51): 53886–91. doi :10.1074/jbc.M407708200 PMID 15471860 . Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB (2004). "Acid-induced pain and its modulation in humans" . J. Neurosci . 24 (48): 10974–9. doi :10.1523/JNEUROSCI.2619-04.2004 PMC 6730214 PMID 15574747 . Su X, Li Q, Shrestha K, Cormet-Boyaka E, Chen L, Smith PR, Sorscher EJ, Benos DJ, Matalon S, Ji HL (2006). "Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator" . J. Biol. Chem . 281 (48): 36960–8. doi :10.1074/jbc.M608002200 PMID 17012229 .
