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| 2016 Milex Open | |
|---|---|
| Date | 7 February – 15 February |
| Edition | 2nd |
| Draw | 32S / 16D |
| Prize money | $50,000+H |
| Surface | Green clay |
| Location | Santo Domingo, Dominican Republic |
| Champions | |
| Singles | |
 Guido Andreozzi | |
| Doubles | |
 Ariel Behar /  Giovanni Lapentti | |
The 2016 Milex Open was a professional tennis tournament played on green clay courts. It was the second edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Santo Domingo, Dominican Republic between 8 February and 14 February 2016.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 DOM
|
Víctor Estrella Burgos | 58 | 1 |
| ARG
|
Horacio Zeballos | 118 | 2 |
 AUT
|
Gerald Melzer | 120 | 3 |
 ESP
|
Roberto Carballés Baena | 129 | 4 |
 SVK
|
Andrej Martin | 141 | 5 |
 COL
|
Alejandro González | 151 | 6 |
 BRA
|
André Ghem | 153 | 7 |
| BRA
|
João Souza | 154 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Guido Andreozzi def. Nicolás Kicker, 6–0, 6–4 Ariel Behar / Giovanni Lapentti def. 
Jonathan Eysseric / 
Franko Škugor, 7–5, 6–4
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