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Semgale (Letties Zemgale) is een van die vier historiese provinsies in Letland. Dit lê aan die westekant van die Daugava (Duits: Düna), en grens aan Lyfland, Latgale en Koerland. Die oostelike deel van Semgale staan soms ook bekend as Bo-Letland.
Die grootste toeristeaantreklikheid is die kasteel van Rundale in Bauska (Duits Bauske).
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