Histopathology image classification: Highlighting the gap between manual analysis and AI automation

To take something with a "grain of salt" or "pinch of salt" is an English idiom that suggests to view something, specifically claims that may be misleading or unverified, with skepticism or not to interpret something literally.^[1]

In the old-fashioned English units of weight, a grain weighs approximately 65 mg, which is about how much table salt a person might pick up between the fingers as a pinch.

The phrase is thought to come from Pliny the Elder's Naturalis Historia, regarding the discovery of a recipe written by the Pontic king Mithridates to make someone immune to poison.^[2] One of the ingredients in the recipe was a grain of salt. Threats involving poison were thus to be taken "with a grain of salt", and therefore less seriously.

The phrase cum grano salis ("with a grain of salt") is not what Pliny wrote. It is constructed according to the grammar of modern European languages rather than Classical Latin. Pliny's actual words were addito salis grano ("after having added a grain of salt").

The Latin word sal (salis is the genitive) means both "salt" and "wit", thus the Latin phrase cum grano salis could be translated to either "with a grain of salt" or "with a grain of wit", actually to "with caution"/cautiously.^[3]

The phrase is typically said "with a pinch of salt" in British English and said "with a grain of salt" in American English.^[4]

• The dictionary definition of with a grain of salt at Wiktionary