Histopathology image classification: Highlighting the gap between manual analysis and AI automation

Central Italy Italia centrale (Italian) Centro Italia (Italian)
Country	Italy
Regions	List Lazio Marche Toscana Umbria
Area
• Total	58,052 km2 (22,414 sq mi)
Population [1]
• Estimate  (2023 est.)	11,680,843
Languages
– Official language	Italian
– Other common languages	Central Italian Tuscan

Central Italy (Italian: Italia centrale or Centro Italia) is one of the five official statistical regions of Italy used by the National Institute of Statistics (ISTAT), a first-level NUTS region, and a European Parliament constituency.

Central Italy encompasses four of the country's 20 regions:

• Lazio
• the Marches (Marche)
• Tuscany (Toscana)
• Umbria

The easternmost and southernmost parts of Lazio (Cittaducale, Amatrice, Sora, Cassino, Isola del Liri, Sperlonga, Fondi, Gaeta and Formia districts, as well as the islands of Ponza and Ventotene) are sometimes connected to southern Italy (the so-called Mezzogiorno) for cultural and historical reasons since they were once part of the Kingdom of the Two Sicilies, and southern Italian dialects are spoken.

As a geographical region, however, central Italy may also include the regions of Abruzzo and Molise,^[2][3][4] which are otherwise considered part of southern Italy for socio-cultural, linguistic and historical reasons.

Central Italy is crossed by the northern and central Apennines and is washed by the Adriatic Sea to the east, by the Tyrrhenian Sea and the Ligurian Sea to the west. The main rivers of this portion of the territory are the Arno and the Tiber with their tributaries (e.g. Aniene), and the Liri-Garigliano. The most important lakes are Lake Trasimeno, Lake Montedoglio, Lake Bolsena, Lake Bracciano, Lake Vico, Lake Albano and Lake Nemi. From an altimetric point of view, central Italy has a predominantly hilly territory (68.9%). The mountainous and flat areas are equivalent to 26.9% and 4.2% of the territorial distribution respectively.

For centuries before the unification of Italy, which occurred in 1861, central Italy was divided into two states: the Papal States and the Grand Duchy of Tuscany.

The Papal States, officially the State of the Church, were a series of territories in the Italian Peninsula under the direct sovereign rule of the pope from 756 until 1870.^[5] They were among the major states of Italy from the 8th century until the unification of Italy, between 1859 and 1870.

The state had its origins in the rise of Christianity throughout Italy and, with it, the rising influence of the Christian Church. By the mid-8th century, with the decline of the Byzantine Empire in Italy, the papacy became effectively sovereign. Several Christian rulers, including Frankish kings Charlemagne and Pepin the Short, donated further lands to be governed by the Church.^[5] During the Renaissance, the papal territory expanded greatly, and the Pope became one of Italy's most important secular rulers as well as the head of the Church. At their zenith, the Papal States covered most of the modern Italian regions of Lazio, which includes Rome; Marche; Umbria; Romagna; and portions of Emilia. Those holdings were considered to be a manifestation of the temporal power of the pope, as opposed to his ecclesiastical primacy.

By 1861, much of the Papal States' territory had been conquered by the Kingdom of Italy. Only Lazio, including Rome, remained under the pope's temporal control. In 1870, the pope lost Lazio and Rome and had no physical territory at all except the Leonine City of Rome, which the new Italian state did not occupy militarily despite its annexation of Lazio. In 1929, the Italian fascist leader Benito Mussolini, the head of the Italian government, ended the "Prisoner in the Vatican" problem involving a unified Italy and the Holy See by negotiating the Lateran Treaty, signed by the two parties. The treaty recognized the sovereignty of the Holy See over a newly created international territorial entity, a city-state within Rome limited to a token territory that became the Vatican City.

The Grand Duchy of Tuscany was an Italian monarchy that existed, with interruptions, from 1569 to 1860 and replaced the Republic of Florence.^[6] The grand duchy's capital was Florence. In the 19th century, the population of the grand duchy was about 1,815,000 inhabitants.^[7]

Having brought nearly all Tuscany under his control after he had conquered the Republic of Siena, Cosimo I de' Medici was elevated by a papal bull of Pope Pius V to Grand Duke of Tuscany on August 27, 1569.^[8][9] The grand duchy was ruled by the House of Medici until the extinction of its senior branch in 1737. While not as internationally renowned as the old republic, the grand duchy thrived under the Medici and bore witness to unprecedented economic and military success under Cosimo I and his sons until the reign of Ferdinando II, which saw the beginning of the state's long economic decline. It peaked under Cosimo III.^[10]

Francis Stephen of Lorraine, a cognatic descendant of the Medici, succeeded the family and ascended the throne of his Medicean ancestors. Tuscany was governed by a viceroy, Marc de Beauvau-Craon, for his entire rule. His descendants ruled and resided in the grand duchy until its end in 1859, barring one interruption, when Napoleon Bonaparte gave Tuscany to the House of Bourbon-Parma (Kingdom of Etruria, 1801–1807) and later annexed it directly to the First French Empire. After the collapse of the Napoleon in 1814, the grand duchy was restored. The United Provinces of Central Italy, a client state of the Kingdom of Sardinia, annexed Tuscany in 1859. Tuscany was formally annexed to Sardinia in 1860 as part of the Unification of Italy after a landslide referendum in which 95% of voters approved.^[11][12]

In 2023, the population in central Italy amounts to 11,680,843 inhabitants.^[1]

Region	Capital	Inhabitants
Lazio	Rome	5,703,289
Marche	Ancona	1,478,881
Toscana	Florence	3,647,054
Umbria	Perugia	851,619

Here is the population residing in 2023 in municipalities with more than 50,000 inhabitants:^[1]

#	Municipality	Region	Inhabitants
1	Rome	Lazio	2,746,639
2	Florence	Toscana	360,444
3	Prato	Toscana	195,906
4	Perugia	Umbria	161,375
5	Livorno	Toscana	152,138
6	Latina	Lazio	127,321
7	Terni	Umbria	106,121
8	Ancona	Marche	98,292
9	Arezzo	Toscana	96,176
10	Pesaro	Marche	95,352
11	Guidonia Montecelio	Lazio	89,191
12	Pistoia	Toscana	89,000
13	Pisa	Toscana	88,726
14	Lucca	Toscana	88,724
15	Fiumicino	Lazio	81,855
16	Grosseto	Toscana	81,154
17	Aprilia	Lazio	74,240
18	Massa	Toscana	65,933
19	Viterbo	Lazio	65,927
20	Pomezia	Lazio	64,246
21	Viareggio	Toscana	60,416
22	Carrara	Toscana	59,786
23	Fano	Marche	59,732
24	Anzio	Lazio	58,946
25	Foligno	Umbria	55,068
26	Tivoli	Lazio	54,908
27	Siena	Toscana	52,657
28	Velletri	Lazio	52,542
29	Civitavecchia	Lazio	51,678

Central Italy is dominated by Central Italian and the Tuscan dialect. Other languages spoken are Gallo-Piceno ("Gallo-Italic Marche" or "Gaul-Marche"), a Gallo-Italic language spoken in the Province of Pesaro and Urbino and in the northern part of the province of Ancona, Marche region,^[13] and Neapolitan, spoken in southern Lazio and in southern Marche as well as eastern fringes of Umbria.

Central Italian refers to the dialects of Italo-Romance spoken in the so-called Area Mediana, which covers a swathe of central Italy. Area Mediana is also used in a narrower sense to describe the southern part in which case the northern one may be referred to as the Area Perimediana, a distinction that will be made throughout this article. The two areas are divided along a line running approximately from Rome in the southwest to Ancona in the northeast.^[14]

In the Early Middle Ages, Central Italian extended north into Romagna and covered all of modern-day Lazio, Abruzzo, and Molise. Since then, however, the dialects spoken in those areas have been assimilated into Gallo-Italic and Southern Italo-Romance respectively.^[15] In addition, the dialect of Rome has undergone considerable Tuscanization from the fifteenth century onwards, such that it has lost many of its central Italian features.^[16][17]

Tuscan dialect is a set of Italo-Dalmatian varieties of Romance spoken in Tuscany, Corsica, and Sardinia. Standard Italian is based on Tuscan, specifically on its Florentine dialect, and it became the language of culture throughout Italy^[18] because of the prestige of the works by Dante Alighieri, Petrarch, Giovanni Boccaccio, Niccolò Machiavelli, and Francesco Guicciardini. It would later become the official language of all Italian states and of the Kingdom of Italy when it was formed. Corsican on the island of Corsica and the Corso-Sardinian transitional varieties spoken in northern Sardinia (Gallurese and Sassarese) are classified by scholars as a direct offshoot from medieval Tuscan,^[19] even though they now constitute a distinct linguistic group.

Marche, Tuscany, and Umbria, together with Emilia-Romagna, are considered to be the most left-leaning regions in Italy and together are also referred to as the "Red Belt".^{[20][21][22][23]}

The gross domestic product (GDP) of the region was 380.9 billion euro in 2018, accounting for 21.6% of Italy's economic output. The GDP per capita adjusted for purchasing power was 31,500 euro, or 105% of the EU27 average the same year.^[24]

The regions of Central Italy were exposed to different historical influences because of the peoples that settled there, such as the Celts, the Etruscans, the North Picenes, the South Picene, the Umbri, the Latins, the Romans, the Byzantines and the Lombards. Some of its woodlands and mountains are preserved in several National Parks; a major example is the Abruzzo, Lazio and Molise National Park, located in Abruzzo, with smaller parts in Lazio and Molise. It is the oldest in the Apennine Mountains and the second-oldest in Italy, with an important role in the preservation of endemic species such as the Italian wolf, Abruzzo chamois and Marsican brown bear.

Central Italy has many major tourist attractions, many of which are protected by UNESCO. Central Italy is possibly the most visited in Italy and contains many popular attractions as well as sought-after landscapes. Rome boasts the remaining wonders of the Roman Empire and some of the world's best-known landmarks, such as the Colosseum. Florence, regarded as the birthplace of the Italian Renaissance, is Tuscany's most visited city, and nearby cities like Siena, Pisa, Arezzo and Lucca also have rich cultural heritage. Umbria's population is small, but it has many important cities such as Perugia and Assisi. For similar reasons, Lazio and Tuscany are some of Italy's most visited regions and the main targets for Ecotourism. The area is known for its picturesque landscapes and attracts tourists from all over the world, including Italy itself. Pristine landscapes serve as one of the primary motivators for tourists to visit central Italy, although there are others, such as a rich history of art.

Roman cuisine comes from the Italian city of Rome. It features fresh, seasonal and simply prepared ingredients from the Roman Campagna.^[25] Then include peas, globe artichokes and fava beans, shellfish, milk-fed lamb and goat, and cheeses such as pecorino romano and ricotta.^[26] Olive oil is used mostly to dress raw vegetables, and strutto (pork lard) and fat from prosciutto are preferred for frying.^[25] The most popular sweets in Rome are small individual pastries called pasticcini, gelato and handmade chocolates and candies.^[27] Special dishes are often reserved for different days of the week; for example, gnocchi is eaten on Thursdays, baccalà (salted cod) on Fridays, and trippa on Saturdays.

• National Institute of Statistics (Italy)
• NUTS statistical regions of Italy
• Italian NUTS level 1 regions:
  • Northwest Italy
  • Northeast Italy
  • South Italy
  • Insular Italy
• Northern Italy
• Southern Italy

42°18′35″N 13°14′58″E / 42.3097°N 13.2494°E / 42.3097; 13.2494